Reversible Nanogate System for Mesoporous Silica Nanoparticles Based on Diels-Alder Adducts

Chemistry : a European Journal
Rafael R CastilloMaría Vallet-Regí

Abstract

The implementation of nanoparticles as nanomedicines requires sophisticated surface modifications to reduce the immune response and enhance recognition abilities. Mesoporous silica nanoparticles present extraordinary host-guest abilities and facile surface functionalization. These two factors make them ideal candidates for the development of novel drug-delivery systems, at the expense of increasing structural complexity. With this idea in mind, a system composed of triggerable and tunable silica nanoparticles was developed for application as drug-delivery nanocarriers. Diels-Alder cycloaddition adducts were chosen as thermal-responsive units that permitted the binding of gold nanocaps able to block the pores and allow the incorporation of targeting fragments. The capping efficiency was tested under different thermal conditions to give outstanding efficiencies within the physiological range and mild temperatures, as well as enhanced release under pulsing heating cycles, which showed the best release profiles.

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Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Aug 3, 2019·Pure and Applied Chemistry. Chimie Pure Et Appliquée·María Vallet-Regí
Feb 8, 2020·Biomacromolecules·Sjoerd J RijpkemaDaniela A Wilson

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