Reversible oligohydramnios in the second trimester of pregnancy in two patients with long-term diclofenac exposure

Reproductive Toxicology
Stephan ScherneckChristof Schaefer

Abstract

The use of non-steroidal anti-inflammatory drugs like diclofenac in the third trimester of pregnancy can cause severe side effects, in particular oligohydramnios, premature closure of ductus arteriosus, and fetal kidney damage. However, the treatment with non-steroidal anti-inflammatory drugs until gestational week 28 is accepted as relatively safe. Here we describe two retrospectively reported cases of early-onset oligohydramnios associated with long-term diclofenac exposure of at least 150mg per day. The pathological findings were detected at gestational weeks 22 and 23, respectively. Amniotic fluid turned to normal after discontinuation of diclofenac in both cases, suggesting causality. Although early-onset oligohydramnios is a rare complication, caution for long-term diclofenac use in high doses is recommended even before gestational week 28.

References

Aug 20, 2004·Pharmacological Reviews·Daniel L SimmonsTimothy Hla
Dec 16, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M R TorloniA F Moron
May 13, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Farid BoubredUmberto Simeoni
Aug 24, 2006·Annals of Tropical Paediatrics·Esad KokluM Hakan Poyrazoglu
Feb 11, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kyohei ShintakuYasufumi Sawada
May 5, 2010·Reproductive Toxicology·Matteo CassinaMaurizio Clementi
Jul 26, 2011·American Journal of Perinatology·Gael Abou-GhannamAnwar H Nassar
Feb 4, 2012·Current Drug Metabolism·Roberto AntonucciVassilios Fanos
Feb 15, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Varsha PhadkeSujata Kanhere
May 27, 2014·American Journal of Perinatology·Richard M Benoit, Ahmet A Baschat

❮ Previous
Next ❯

Citations

May 14, 2016·Expert Review of Clinical Immunology·Frauke Förger, Peter M Villiger
May 21, 2021·Reproductive Toxicology·Stefanie HultzschKatarina Dathe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.