Reversible p Ka Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions

ACS Applied Materials & Interfaces
Yu HoshinoYoshiko Miura

Abstract

The acid dissociation constants (p Ka values) of Brønsted acids at the active sites of proteins are reversibly modulated by intramolecular electrostatic interactions with neighboring ions in a reaction cycle. The resulting p Ka shift is crucial for the proteins to capture, transfer, and release target ions. On the other hand, reversible p Ka modulation through electrostatic interactions in synthetic polymer materials has seldom been realized because the interactions are strongly shielded by solvation water molecules in aqueous media. Here, we prepared hydrogel nanoparticles (NPs) bearing carboxylic acid groups whose p Ka values can be reversibly modulated by electrostatic interactions with counterions in the particles. We found that the deprotonated states of the acids were stabilized by electrostatic interactions with countercations only when the acids and cations were both imprinted in hydrophobic microdomains in the NPs during polymerization. Cationic monomers, like primary amine- and guanidium group-containing monomers, which interacted strongly with growing NPs showed greater p Ka modulation than monomers that did not interact with the NPs, such as quaternary ammonium group-containing monomers. Modulation was enhanced when...Continue Reading

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Citations

Jul 10, 2019·Chemistry : a European Journal·Hang YinDavid Bardelang
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen QianHiroshi Uyama

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