Reversible peripheral neuropathy in idiopathic hypoparathyroidism

Acta Neurologica Scandinavica
Ravinder GoswamiNarayana Kochupillai

Abstract

We describe a 40-year-old male with idiopathic hypoparathyroidism presenting with tetany, proximal weakness, signs of hypocalcaemia including Chvostek and Trousseau's and diminished tendon reflexes in the upper and lower limbs. Electrophysiological studies revealed a sensory-motor neuropathy, predominantly axonal as evidenced by decreased CMAP amplitudes, with normal distal latencies-velocites, except for median nerve where a prolonged distal latency was observed. Serial nerve conduction studies were performed at repeated intervals for 2 years, while he received treatment for hypoparathyroidism (calcium and vitamin D supplementation). A progressive improvement in neuropathy both clinical and on electrophysiological studies was observed. Occurrence of peripheral neuropathy in hypocalcaemic states such as hypoparathyroidism and its reversibility after normalization of calcium homeostasis lend proof to the role of critical Ca2+ ion concentration in the normal functioning of the peripheral axons.

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Citations

Sep 22, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Thomas ZambelisConstantinos Potagas
Jun 2, 2012·Journal of Chiropractic Medicine·Ralph A Kruse, Jerrilyn A Cambron
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Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Soma Saha, Ravinder Goswami
Feb 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Soma SahaRavinder Goswami

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