Reversible photoresponsive activity of a carbonic anhydrase mimic

Chemical Communications : Chem Comm
Monochura Saha, Subhajit Bandyopadhyay

Abstract

The carbonic anhydrase (CA) enzyme reversibly transforms carbon dioxide and water to a carbonate ion and a proton. Photoresponsive enzyme mimics, where the CA-activity can be turned on and off reversibly with light, have not been reported so far. We have designed an active site mimic that offers reversible control of the catalytic activity using light. Moreover, in the presence of a cationic polymer, we have demonstrated that the CA-activity was further enhanced by stabilizing the transition state with the cis-form of the enzyme mimic which can catalyze the hydration of gaseous CO2.

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Citations

Aug 9, 2019·Chemistry, an Asian Journal·Monochura SahaSubhajit Bandyopadhyay
Mar 14, 2020·Chemical Communications : Chem Comm·Munshi Sahid HossainSubhajit Bandyopadhyay
Sep 22, 2020·Beilstein Journal of Organic Chemistry·Jannis LudwigRainer Herges
Nov 13, 2020·Angewandte Chemie·Monochura SahaSubhajit Bandyopadhyay
Apr 17, 2021·The Journal of Organic Chemistry·Munshi Sahid Hossain, Subhajit Bandyopadhyay

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Methods Mentioned

BETA
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