PMID: 20630137Jul 16, 2010Paper

Reversible posterior leukoencephalopathy syndrome in a patient with severe uremic encephalopathy

Clinical Nephrology
N TatsumotoM Iida

Abstract

A 59-year-old male presented at our hospital with disturbance of consciousness. He had severe neurological disturbances associated with uremia caused by severe renal insufficiency. Cranial computed tomography (CT) was normal on admission. FLAIR-weighted MRI showed increased signal intensities bilaterally in the cortical and subcortical areas of the occipital lobe. Repeated hemodialysis resulted in improvement of the clinical symptoms and blood chemistry, and normalization of the MRI findings. Although the patient was discharged without neurological deficit, he had to be maintained on regular intermittent hemodialysis due to persistent renal failure. These reversible neuroradiological abnormalities may have been caused by reversible brain edema, but other pathoetiological factors should be also considered, such as abnormalities of cerebral metabolism and effects of uremic toxins.

Citations

Dec 18, 2013·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Vivek B KuteAruna V Vanikar
Apr 30, 2016·AJNR. American Journal of Neuroradiology·D M KimC J Song
Jan 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Carlos R Camara-LemarroyDionicio A Galarza-Delgado
May 30, 2017·Case Reports in Medicine·Kiichiro FujisakiKazuhiko Tsuruya

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