Reversible renal failure in a patient with the hypereosinophilia syndrome during therapy with alpha interferon

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
G NassarW Smith

Abstract

Human recombinant interferon (IFN)-alpha (alpha)-2b was given to a 57-year-old man with hypereosinophilia syndrome refractory to prednisone and hydroxyurea. One year later, he developed progressive renal failure and nephrotic-range proteinuria. Percutaneous kidney biopsy showed focal and segmental glomerular and mesangial sclerosis, chronic interstitial nephritis, and focal tubular necrosis. Discontinuation of cytokine therapy led to marked improvement in renal function and significant reduction in proteinuria. The potential role of IFN-alpha as the cause of renal failure and nephrotic-range proteinuria is discussed. The spectrum of renal disease attributed to IFN-alpha and the proposed pathogenic mechanisms are reviewed.

Citations

Mar 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Glen S MarkowitzVivette D D'Agati
Apr 8, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Akash Shukla, Shobna J Bhatia
Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P E Kintzel
Sep 18, 2007·Immunology and Allergy Clinics of North America·Joseph H Butterfield
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F NogakiS Sasayama
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·Ravinder K Wali, William L Henrich
Mar 7, 2021·Biomedicines·Tadej PetreskiSebastjan Bevc

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