Reversible Shielding between Dual Ligands for Enhanced Tumor Accumulation of ZnPc-Loaded Micelles

Nano Letters
Jing CaoZhi Yuan

Abstract

Herein, we report a ligand-reversible-shielding strategy based on the mutual shielding of dual ligands tethered to the surface of nanoparticles. To exemplify this concept, phenylboronic acid-functionalized poly(ethylene glycol)- b-poly(ε-caprolactone) (PBA-PEG-PCL) and galactose-functionalized diblock polymer (Gal-PEG-PCL) were mixed to form dual-ligand micelles (PBA/Gal). PBA and Gal residues could form a complex at pH 7.4 and mutually shield their targeting function. At pH 6.8, the binding affinity between PBA and Gal weakened, and PBA preferred to bind with the sialic acid residues on the tumor cell surface rather than to Gal on the micellar surface; furthermore, the unbound Gal recovered its targeting ability toward the asialoglycoprotein receptor. When the pH decreased from 7.4 to 6.8, enzyme-linked immunosorbent assays exhibited that the percentage of exposed Gal on the micellar surface increased 1.9-fold, and flow cytometry showed that HepG2 cellular uptake increased 4.3-fold. More importantly, this process was reversible, confirming the reversible shielding and deshielding of dual ligands. With the encapsulation of a photosensitizer, zinc phthalocyanine (ZnPc), the reversible-shielding micelles showed a 48% improvement ...Continue Reading

References

Sep 1, 1993·British Journal of Cancer·T VolkM F Rajewsky
Mar 20, 2003·Journal of the American Chemical Society·Hidenori OtsukaKazunori Kataoka
Mar 30, 2005·Nano Letters·Eun Seong LeeYou Han Bae
Jan 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vijay A Sethuraman, You Han Bae
Nov 13, 2009·Nano Letters·Tal DvirDaniel S Kohane
Aug 21, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Chunsoo KimTae Gwan Park
Jun 10, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mingrong ChengRunjiao Zhou
Aug 3, 2011·Chemical Communications : Chem Comm·Francesca MastrottoStefano Salmaso
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amy DaviesZoe Pikramenou
Dec 21, 2012·Journal of the American Chemical Society·Erlei JinMaciej Radosz
Mar 8, 2013·Journal of the American Chemical Society·Jing ZhangXian-Zheng Zhang
Jun 25, 2013·Nature Biotechnology·Gaurav SahayDaniel G Anderson
Sep 14, 2013·Journal of the American Chemical Society·Stephanie DeshayesKazunori Kataoka
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Jun 3, 2014·Nano Letters·Aoune BarhoumiDaniel S Kohane
Sep 19, 2014·ACS Applied Materials & Interfaces·Zhiqing TianZhi Yuan
Dec 29, 2015·Colloids and Surfaces. B, Biointerfaces·Chengling YangZhi Yuan
Apr 5, 2016·Chemical Communications : Chem Comm·Jingjing ZhaoJun-Jie Zhu
May 28, 2016·ACS Applied Materials & Interfaces·Dan ZhaoFeng Li
Jul 5, 2016·Theranostics·Xin WangXiqun Jiang
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
May 31, 2017·Frontiers in Immunology·Marc J PallardyArmelle Biola-Vidamment
Sep 13, 2017·Chemical Reviews·Madduri Srinivasarao, Philip S Low
Oct 17, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhenpeng HuZhi Yuan
Dec 20, 2017·ACS Nano·Christopher M HartshornPiotr Grodzinski
Mar 22, 2018·Journal of the American Chemical Society·Jie GaoDong-Sheng Guo
May 8, 2018·Molecular Pharmaceutics·Neetu M GulatiNicole F Steinmetz
Jun 30, 2018·Chemical Reviews·Horacio CabralKazunori Kataoka
Aug 23, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jiwei CuiFrank Caruso
Apr 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan ZhaoFeng Li

❮ Previous
Next ❯

Citations

Jul 30, 2019·Advanced Materials·Peng MiKazunori Kataoka
Mar 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yahui ZhangZhi Yuan
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·E K Pramod KumarJae Hyung Park
Jan 26, 2021·International Journal of Nanomedicine·Bo LianGuixiang Tian
May 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yilin ChenXuan Zhu
Jun 16, 2021·ACS Biomaterials Science & Engineering·Zhenjie ZhangZhi Yuan
Jul 2, 2021·Chemical Communications : Chem Comm·Fei LuBo Tang
Sep 20, 2020·International Journal of Pharmaceutics·Lei LiuGuang Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved