Reversible splenial lesion in the corpus callosum following rapid withdrawal of carbamazepine after neurosurgical decompression for trigeminal neuralgia

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Harushi MoriKuni Ohtomo

Abstract

Reversible splenial lesions (RSL) of the corpus callosum have been described in various clinical conditions, and some are attributed to the action of antiepileptic drugs (AED). Abrupt withdrawal of an AED in preparation for surgical treatment can result in RSL of the corpus callosum in patients with trigeminal neuralgia who do not have epilepsy. We report two patients who developed RSL following surgical treatment of trigeminal neuralgia. Since our two patients did not have epilepsy, it is strongly suggested that the AED, rather than convulsive status epilepticus, could be a contributing factor in RSL. The pathogenesis of AED-associated RSL is not clear. Similar RSL can appear under various circumstances, implying that factors other than AED can influence a common end-point mechanism that results in RSL. Nevertheless, delirium after surgery may be a cue for inquiring about RSL. This condition is transient and represents a clinicoradiological syndrome with an excellent prognosis. We should consider this phenomenon in the perioperative period after surgery for trigeminal neuralgia to avoid invasive diagnostic and therapeutic procedures.

References

Jun 3, 1978·British Medical Journal·W P StephensP H Baylis
Jun 11, 2003·Neurology·Seyed M MirsattariWarren T Blume
Mar 16, 2005·Archives of Neurology·Michael J DohertyDan K Hallam
Oct 17, 2006·Journal of Neuroradiology. Journal De Neuroradiologie·M MaedaJ I Takanashi
Mar 3, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro HondaTatsuhiko Yuasa
Mar 11, 2008·Seizure : the Journal of the British Epilepsy Association·Kerstin AnnekenMichael Deppe
May 21, 2008·Brain & Development·Jun-ichi TakanashiA James Barkovich
Sep 17, 2008·Brain & Development·Jun-ichi TakanashiA James Barkovich
Feb 3, 2009·Epilepsia·Gudrun GröppelChristoph Baumgartner
Jan 1, 2010·Journal of the Neurological Sciences·Takuji ImamuraAkira Nishimura

❮ Previous
Next ❯

Citations

Apr 22, 2014·Seminars in Ultrasound, CT, and MR·Carolina de Medeiros RimkusLeandro Tavares Lucato
Oct 28, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Fumiaki UedaToshifumi Gabata
Dec 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Chellamani HariniSanjeev V Kothare
Jun 1, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tae-Won KimJoong-Seok Kim
Apr 20, 2017·Internal Medicine·Yasuhiro FuseyaSadayuki Matsumoto
Jan 15, 2019·La Revue de médecine interne·C MaroisN Weiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

© 2022 Meta ULC. All rights reserved