Abstract
Reversible splenial lesions (RSL) of the corpus callosum have been described in various clinical conditions, and some are attributed to the action of antiepileptic drugs (AED). Abrupt withdrawal of an AED in preparation for surgical treatment can result in RSL of the corpus callosum in patients with trigeminal neuralgia who do not have epilepsy. We report two patients who developed RSL following surgical treatment of trigeminal neuralgia. Since our two patients did not have epilepsy, it is strongly suggested that the AED, rather than convulsive status epilepticus, could be a contributing factor in RSL. The pathogenesis of AED-associated RSL is not clear. Similar RSL can appear under various circumstances, implying that factors other than AED can influence a common end-point mechanism that results in RSL. Nevertheless, delirium after surgery may be a cue for inquiring about RSL. This condition is transient and represents a clinicoradiological syndrome with an excellent prognosis. We should consider this phenomenon in the perioperative period after surgery for trigeminal neuralgia to avoid invasive diagnostic and therapeutic procedures.
References
Jun 3, 1978·British Medical Journal·W P StephensP H Baylis
Sep 1, 1982·Neurosurgery·T DócziJ Kiss
Jun 11, 2003·Neurology·Seyed M MirsattariWarren T Blume
Aug 28, 2003·European Radiology·Masayuki MaedaKan Takeda
Mar 16, 2005·Archives of Neurology·Michael J DohertyDan K Hallam
Sep 30, 2005·Epilepsia·Olga PrilipkoMargitta Seeck
Oct 12, 2005·Neurology·S GürtlerF G Woermann
May 5, 2006·Neuroradiology·M NellesH Urbach
Oct 17, 2006·Journal of Neuroradiology. Journal De Neuroradiologie·M MaedaJ I Takanashi
Mar 3, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro HondaTatsuhiko Yuasa
Mar 11, 2008·Seizure : the Journal of the British Epilepsy Association·Kerstin AnnekenMichael Deppe
May 21, 2008·Brain & Development·Jun-ichi TakanashiA James Barkovich
Sep 17, 2008·Brain & Development·Jun-ichi TakanashiA James Barkovich
Feb 3, 2009·Epilepsia·Gudrun GröppelChristoph Baumgartner
Jan 1, 2010·Journal of the Neurological Sciences·Takuji ImamuraAkira Nishimura
Citations
Apr 22, 2014·Seminars in Ultrasound, CT, and MR·Carolina de Medeiros RimkusLeandro Tavares Lucato
Oct 28, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Fumiaki UedaToshifumi Gabata
Dec 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Chellamani HariniSanjeev V Kothare
Jan 7, 2014·Journal of the Neurological Sciences·Min-Jie ChenYun-Wu Li
Jun 1, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tae-Won KimJoong-Seok Kim
Sep 30, 2016·Medicine·Chunrong LiHong-Liang Zhang
Feb 13, 2015·Medicine·Shuo ZhangJuan Feng
Apr 20, 2017·Internal Medicine·Yasuhiro FuseyaSadayuki Matsumoto
Apr 19, 2018·Pediatric Radiology·Anthony Le BrasBertrand Bruneau
Mar 6, 2021·AJNR. American Journal of Neuroradiology·H ToiM Uno
Jan 15, 2019·La Revue de médecine interne·C MaroisN Weiss