PMID: 6991444Jan 1, 1980Paper

Reversible suppression of allo-antibody production by cyclosporin A

International Archives of Allergy and Applied Immunology
S DenhamC J Dean

Abstract

Treatment of rats with 25 mg/kg/day of cyclosporin A suppressed their immune response to skin allografts. Withdrawal of cyclosporin A treatment led to complete recovery of specific immune responsiveness and the time taken for recovery was independent of the duration of treatment. Titration of the dose of cyclosporin A administered in vivo indicated that doses of 12 mg/kg/day or less were not fully immunosuppressive.

Citations

Oct 1, 1982·The Journal of Pathology·J T BlairJ G Simpson
Mar 1, 1995·The Journal of International Medical Research·N SuzakiK Orita
May 1, 1981·Scandinavian Journal of Immunology·L Andrus, K J Lafferty
Oct 1, 1984·Agents and Actions·A W ThomsonJ G Simpson

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