PMID: 11918511Mar 29, 2002Paper

Reversible thrombocytopenia associated with eptifibatide

The Annals of Pharmacotherapy
Monty Yoder, Rebecca F Edwards

Abstract

To report a patient who experienced severe, reversible thrombocytopenia after receiving eptifibatide for acute coronary syndrome. A 61-year-old white man with a past medical history of coronary artery disease, peripheral vascular disease, insulin-dependent diabetes, hypertension, and dyslipidemia was treated with eptifibatide as an adjunct to standard antiischemic therapy for acute coronary syndrome. On administration of eptifibatide, the patient experienced chills accompanied by sharp pains that radiated throughout his body. The infusion was immediately stopped and the symptoms resolved. A platelet count obtained 11 hours later showed a decrease from a baseline of 230 to 3 x 10(3)/mm(3) (normal 160-360). Multiple platelet analyses confirmed profound thrombocytopenia. Over the course of the hospitalization, the patient's platelet count returned to normal; he experienced no other adverse hematologic sequelae. All of the glycoprotein IIb/IIIa receptor antagonists are associated with thrombocytopenia. However, the risk of thrombocytopenia has been observed to be less with eptifibatide. Because of the temporal relationship between eptifibatide administration and the patient's symptoms and laboratory analysis, we believe that the th...Continue Reading

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Citations

Nov 8, 2003·Progress in Cardiovascular Nursing·Raymond Ho, Steven R Kayser
Mar 12, 2003·Pharmacotherapy·Jeff NaggePeter Seidelin
Feb 18, 2006·Journal of Interventional Cardiology·Aamir Adnan CheemaMarc Oliver Gosselin
Dec 31, 2009·Journal of Interventional Cardiology·Chetan Shenoy, Kishore J Harjai
Jan 13, 2005·The Annals of Pharmacotherapy·James C CoonsMichael F Hagerty
Nov 17, 2007·Journal of Thrombosis and Thrombolysis·Marwan RefaatDaniel Edmundowicz
Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Sep 30, 2006·Journal of Thrombosis and Thrombolysis·Slava EpelmanArman T Askari
Dec 6, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·S M SaidR Prondzinsky

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