PMID: 5257013Mar 1, 1969Paper

Reversible transformation of fibrous collagen to a soluble state in vivo

Proceedings of the National Academy of Sciences of the United States of America
L Klein

Abstract

Metabolic pathways of pre-existing and newly synthesized collagen fractions from skin and induced connective tissue were studied in rats that had been labeled with (3)H-L-proline 6 and 20 weeks previously. The distribution of specific radioactivity was determined for soluble and insoluble collagens. Multiple extractions of neutral salt-soluble and citrate-soluble collagen demonstrated constant specific radioactivities which indicated the achievement of an isotopic steady state. Citrate-soluble collagen was four times more radioactive than neutral salt-soluble collagen, which indicated a large difference in biological age (months) between fractions. Different levels of specific radioactivity in collagen fractions from implanted sponge indicated that both pre-existing (citrate-soluble) and newly synthesized collagen (salt-soluble) contributed to the insoluble collagen of induced connective tissue in normal and hypophysectomized rats. The isotopic data indicated that pre-existing fibrous collagen could be solubilized in vivo and translocated from skin to sponge via citrate-soluble collagen.

References

Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·L R Klein, P H Weiss
Aug 13, 1968·Biochimica Et Biophysica Acta·A J Bailey
Jan 6, 1969·Biochemical and Biophysical Research Communications·L KleinC J Nowacek
Jan 1, 1969·The Journal of Clinical Investigation·P H Weiss, L Klein
Nov 22, 1965·Biochemical and Biophysical Research Communications·L Klein, P H Weiss
Nov 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·E KULONENA DORFMAN
Jun 13, 1958·Science·V N OREKHOVITCH, V O SHPIKITER
Aug 26, 1961·Nature·A N DAVISON, J DOBBING
Oct 1, 1962·Biochemical Pharmacology·T NIKKARI, E KULONEN
Feb 1, 1960·The Journal of Biophysical and Biochemical Cytology·D S JACKSON, J P BENTLEY

❮ Previous
Next ❯

Citations

Jun 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·S H Jackson, J A Heininger
Mar 15, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·S H Jackson, J A Heininger
Feb 13, 1975·Biochimica Et Biophysica Acta·S H Jackson, J A Heininger
Feb 1, 1972·Experimental Gerontology·A V Everitt, L Delbridge
Jul 16, 1971·Biochemical and Biophysical Research Communications·D H Henneman
Jan 6, 1969·Biochemical and Biophysical Research Communications·L KleinC J Nowacek
Jan 1, 1974·Seminars in Arthritis and Rheumatism·M E Nimni
May 1, 1980·Prostaglandins and Medicine·R Arumugham, S M Bose
Aug 1, 1983·Seminars in Arthritis and Rheumatism·M E Nimni
Jan 1, 1978·Archives of Oral Biology·W A Orlowski
Mar 1, 1986·Experimental Eye Research·J H LassL Klein
Jul 1, 1977·The Journal of Surgical Research·E D KurshL Persky
Jan 1, 1979·Archives of Oral Biology·C A ShuttleworthP N Hirschmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.