PMID: 9555031May 23, 1998Paper

Reversible translocation of CTP:phosphocholine cytidylyltransferase from cytosol to membranes in the adult bovine liver around parturition

Biochimica Et Biophysica Acta
B A BladergroenM J Geelen

Abstract

The key regulatory enzyme of phosphatidylcholine (PC) synthesis, CTP:phosphocholine cytidylyltransferase (CT), is known to be activated in vitro by translocation from soluble to particulate fractions of the cell. In the present study the periparturient cow was chosen as a model to investigate whether translocation of CT can contribute to the regulation of PC synthesis in vivo. Between parturition and 1.5 weeks post-partum, the cytosolic CT activity in the liver of the adult animal decreased 1.9-fold, and this correlated with a 1.8-fold increase in microsomal CT activity. At that time, microsomal CT activity started to decline again whereas the cytosolic activity rose concomitantly until both activities reached their pre-partum values at 8 weeks post-partum. The activities of soluble and membrane-bound CTP:phosphoethanolamine cytidylyltransferase (ET), the analogous enzyme in the CDP-ethanolamine pathway, did not change significantly throughout this period. Whereas hepatic PC concentrations declined until about 2 weeks post-partum and thereafter gradually returned to pre-partum levels, the PC levels in very-low-density-lipoproteins, started to rise 2 weeks after the partus reaching a maximum of 219% of the original value at 8 we...Continue Reading

References

Jan 1, 1992·Methods in Enzymology·L B TijburgL M van Golde
Jan 1, 1992·Methods in Enzymology·N D Ridgway, D E Vance
Jan 1, 1990·Progress in Lipid Research·C Kent
May 15, 1990·The Biochemical Journal·G M Hatch, P C Choy
May 15, 1989·Biochemical and Biophysical Research Communications·L B TijburgL M Van Golde
Oct 1, 1985·Biochemical Society Transactions·V A Zammit
Nov 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·S L PelechD E Vance
Jan 1, 1995·Annual Review of Biochemistry·C Kent

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Citations

Oct 25, 2013·International Journal of Molecular Sciences·William Raphael, Lorraine M Sordillo

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