Reversible ultrastructural alterations in the myocytic mitochondria of isolated rat hearts induced by oxygen radicals

Ultrastructural Pathology
A C HegstadL Jørgensen

Abstract

The present study focuses on reversible mitochondrial ultrastructural alterations in myocardial myocytes that correspond or accompany reversible metabolic depression observed after oxygen radical exposure. The myocytic mitochondrial membranes and matrix of isolated Langendorff-perfused rat hearts were examined by semiquantitative morphometry using the electron micrograph as unit. The hearts were exposed to either standard perfusion (group A), 10 min of oxygen radicals together with superoxide dismutase and catalase followed by 35 min of recovery (group B), 10 min of oxygen radicals alone (group C), or 10 min of oxygen radicals followed by 35 min of recovery (group D). Mitochondrial ultrastructural alterations were detected in only a few micrographs in groups A and B. The frequency of micrographs with mitochondrial ultrastructural alterations was 69% in group C and 62% in group D. In the group exposed to 10 min of oxygen radicals without recovery (group C) condensed pentalaminar membranous profiles arranged in parallel, interpreted to be closely adhering cristae, were detected in the intracristal compartment of myocytic mitochondria in 50% of the micrographs. The cristal adhesions were associated with other mitochondrial ultrast...Continue Reading

References

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Citations

Oct 26, 1999·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·A C HegstadL Jørgensen
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk

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