Reversible vascular calcifications associated with hypervitaminosis D

Journal of Nephrology
Massimo CirilloChiara Cirillo

Abstract

A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed widespread vascular calcifications, gluteal calcifications, and pelvic ectasia. Subsequent lab tests indicated suppressed serum parathyroid hormone, extremely high serum 25-hydroxy vitamin D, and normal serum 1,25-dihydroxy vitamin D. Treatment was started with intravenous infusion of saline and furosemide due to the evidence of hypercalcemia. Prednisone and omeprazole were added given the evidence of hypervitaminosis D. The treatment improved serum calcium, kidney function, and consciousness. The medical history disclosed recent treatment with exceptionally high doses of slow-release intra-muscular cholecalciferol and the recent excretion of urinary stones. The patient was discharged when it was possible to stop the intravenous treatment. The post-discharge treatment included oral hydration, furosemide, prednisone and omeprazole for approximately 6 months up to complete resolution of the hypercalcemia. The patient...Continue Reading

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Mar 8, 2013·American Journal of Nephrology·Flore DurantonAngel Argilés

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Citations

Mar 3, 2018·British Journal of Clinical Pharmacology·Peter N Taylor, J Stephen Davies
Jul 22, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pablo Ureña-TorresJordi Bover
Jul 15, 2021·Case Reports in Endocrinology·Krystel FeghaliIbitoro Osakwe

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