Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency

BMJ Case Reports
Ahmed Al-sharefi, Rudy Bilous

Abstract

We describe a case of a 35-year-old woman who presented with bilateral leg weakness and encephalopathy while on long-term valproate therapy. She was diagnosed with valproate-induced encephalopathy due to carnitine deficiency. Clinical improvement occurred with oral carnitine supplementation. Our case report highlights the importance of considering carnitine deficiency in patients presenting with unexplained neurological signs while on long-term valproate treatment.

Citations

May 17, 2017·Neurochemical Research·Gustavo C Ferreira, Mary C McKenna
Nov 2, 2019·The American Journal of Psychiatry·Josef BaumgartnerNilufar Mossaheb
Jun 23, 2021·American Journal of Medical Genetics. Part a·Emily R VasiljevskiAaron Schindeler

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