PMID: 2496734Mar 1, 1989Paper

Reversible zidovudine-induced pure red-cell aplasia

AIDS
H CohenI V D Weller

Abstract

The treatment of patients with AIDS and AIDS-related complex (ARC) with zidovudine is limited by major haematological toxicity. In an open study of the use of zidovudine, 10 out of a total of 81 patients developed a severe anaemia within the first 3 months of treatment. In five of these 10 patients the mean cell volume did not increase but remained within the normal range. Bone marrow examination of three of these five showed a pure red-cell aplasia. In all five patients the anaemia resolved on discontinuation of the drug and in three that were re-challenged, the anaemia recurred. Zidovudine-induced anaemia has usually been reported as macrocytic and megaloblastic, but in our experience erythroid aplasia appears to be a major cause of anaemia occurring within the first 3 months of treatment. The earliest sign is anaemia with a stable or only a slight increase in the mean cell volume (MCV).

Citations

Aug 28, 1999·AIDS·P BlancheD Sicard
Nov 2, 2005·AIDS·Robert WeinkoveRanjababu Kulasegaram
Aug 1, 1991·Genitourinary Medicine·L Hughes-DaviesR F Miller
Sep 28, 2010·Indian Journal of Pharmacology·Anuja BalakrishnanRavindra Kumar Agrawal
Sep 8, 2011·Stem Cells·Frédéric MorinetSerge Fichelson
Jan 1, 1990·Clinical and Laboratory Haematology·S G LimP B Kernoff
Oct 17, 2019·Southern African Journal of HIV Medicine·Nithendra ManickchundYunus S Moosa

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