Reversibly Manipulating the Surface Chemistry of Polymeric Nanostructures via a "Grafting To" Approach Mediated by Nucleobase Interactions

Macromolecules
Zan HuaRachel K O'Reilly

Abstract

"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new "grafting to" approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM). PNIPAM chains were distributed throughout the corona and facilitated a fast and fully reversible size change of the resulting mixed-corona micelles upon heating. Through the introduction of an environmentally sensitive fluorophore, the reversible changes in nanoparticle size and coronal composition could be easily probed. Furthermore, preparation of mixed-corona micelles also enabled ligands, such as d-mannose, to be concealed and displayed on the micelle surface. This s...Continue Reading

References

Jan 22, 2002·Physical Review Letters·S MinkoM Stamm
Feb 19, 2002·Chemical Reviews·Halina Lis, Nathan Sharon
Feb 21, 2002·Journal of the American Chemical Society·Christopher W CairoLaura L Kiessling
Oct 14, 2005·Journal of the American Chemical Society·Raymond J ThibaultVincent M Rotello
Mar 17, 2006·Nature·Paul W K Rothemund
Mar 12, 2009·Journal of the American Chemical Society·Pik Kwan Lo, Hanadi F Sleiman
Sep 26, 2009·Journal of the American Chemical Society·Ryan M HensarlingDerek L Patton
Sep 8, 2010·Chemical Communications : Chem Comm·Adam O MoughtonRachel K O'Reilly
Aug 3, 2011·Chemical Communications : Chem Comm·Francesca MastrottoStefano Salmaso
Jan 10, 2012·ACS Applied Materials & Interfaces·Leonid Ionov, Sergiy Minko
Feb 16, 2012·Chemical Society Reviews·Mahmoud Elsabahy, Karen L Wooley
May 3, 2012·Chemical Communications : Chem Comm·Phillip J MilnesRachel K O'Reilly
May 23, 2012·Nature Chemistry·Ronan McHaleRachel K O'Reilly
Feb 8, 2013·Journal of the American Chemical Society·Mathew P RobinRachel K O'Reilly
Jun 15, 2013·Journal of the American Chemical Society·Mathew P RobinRachel K O'Reilly
Jul 25, 2013·Chemical Society Reviews·Patrick TheatoThomas H Epps
Aug 21, 2013·Macromolecular Rapid Communications·Joy Romulus, Marcus Weck
Feb 13, 2014·Chemical Society Reviews·Joseph P PattersonRachel K O'Reilly
Oct 28, 2014·Angewandte Chemie·Evi StahlHendrik Dietz
May 20, 2015·Chemical Communications : Chem Comm·Anne B MabireRachel K O'Reilly
Jan 5, 2016·Chemical Reviews·Elisha KriegBoris Rybtchinski
Feb 9, 2016·Journal of the American Chemical Society·Naiqian ZhanHedi Mattoussi
May 6, 2016·Chemical Society Reviews·Gretchen Marie Peters, Jeffery T Davis
May 20, 2016·Chemical Communications : Chem Comm·Keren ZhangTimothy E Long
Oct 11, 2017·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Sangho WonMatthew I Gibson

❮ Previous
Next ❯

Citations

Feb 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianjun LiChuanbing Tang
Apr 8, 2020·ChemistryOpen·Anselmo Del PradoYi-Lin Wu
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boer LiuTimothy E Long
Jun 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Junfeng WangJun Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
light
Fluorescence
fluorescence spectroscopy

Software Mentioned

Cirrus SEC
Malvern DTS
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.