Reversing bladder outlet obstruction attenuates systemic and tissue oxidative stress

BJU International
Wei-Yu LinYau-Huei Wei

Abstract

What's known on the subject? and What does the study add? Oxidative damage in bladder tissue and systemic oxidative biomarkers were both found to be increased in rabbits with partial bladder outlet obstruction. It is shown that the reversal of partial bladder outlet obstruction will attenuate the systemic oxidative stress. To investigate whether partial bladder outlet obstruction (PBOO) increases systemic oxidative stress and whether relief of PBOO could attenuate this stress. Surgically created PBOO in male New Zealand white rabbits was assessed after 4 weeks in one group of rabbits (n = 4), and was relieved in two additional groups of rabbits (n = 4 each) that were assessed at 4 and 8 weeks after relief of PBOO. Four sham-operated rabbits served as controls. The assessed oxidative stress biomarkers included urinary and plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) and plasma malondialdehyde (MDA), total anti-oxidant capacity (TAC) and glutathione (GSH). In addition, the copy number of mitochondrial DNA and the 8-OHdG content in bladder tissues from these rabbits were also determined at the beginning and at indicated time points in the experiments. There were significant increases in both the 8-OHdG levels of urine, plasma and b...Continue Reading

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Citations

Apr 1, 2014·The Journal of Urology·Douglass B ClaytonGinger L Milne
Oct 30, 2016·Neurourology and Urodynamics·Wei-Yu LinMiaw-Ling Chen
Oct 17, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcio Augusto AverbeckErnani Luis Rhoden
May 11, 2019·Neurourology and Urodynamics·Shelby A PowersJohanna L Hannan
Jan 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Annette SchröderDarius J Bägli
Jun 6, 2013·Molecular and Cellular Biochemistry·Connor M CallaghanRobert M Levin
Jul 3, 2021·International Journal of Molecular Sciences·Yi-Hsuan WuYung-Shun Juan

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