Abstract
The role of glioma stem cells (GSCs) in cancer progression is currently debated; however, it is hypothesised that this subpopulation is partially responsible for therapeutic resistance observed in glioblastoma multiforme (GBM). Recent studies have shown that the current treatments not only fail to eliminate the GSC population but even promote GSCs through reprogramming of glioma non-stem cells to stem cells. Since the standard GBM treatment often requires supplementation with adjuvant drugs such as antidepressants, their role in the regulation of the heterogeneous nature of GSCs needs evaluation. We examined the effects of imipramine, amitriptyline, fluoxetine, mirtazapine, agomelatine, escitalopram, and temozolomide on the phenotypic signature (CD44, Ki67, Nestin, Sox1, and Sox2 expression) of GSCs isolated from a human T98G cell line. These drugs were examined in several models of hypoxia (1% oxygen, 2.5% oxygen, and a hypoxia-reoxygenation model) as compared to the standard laboratory conditions (20% oxygen). We report that antidepressant drugs, particularly imipramine and amitriptyline, modulate plasticity, silence the GSC profile, and partially reverse the malignant phenotype of GBM. Moreover, we observed that, in contrast...Continue Reading
References
Nov 1, 1995·Journal of Clinical Epidemiology·A B Steingart, M Cotterchio
Jul 1, 1994·Annals of Neurology·M J TaphoornJ J Heimans
Jun 1, 1993·Archives of Biochemistry and Biophysics·M V Berridge, A S Tan
Oct 12, 2001·Journal of Neurochemistry·K HisaokaS Yamawaki
Oct 20, 2004·Cancer Research·Dan PeerRimona Margalit
Nov 16, 2004·Current Opinion in Neurology·Larry Junck
Sep 23, 2006·Cancer Research·Michael F ClarkeGeoffrey M Wahl
May 30, 2009·Cancer Cell·Zhizhong LiJeremy N Rich
Apr 9, 2010·Brain : a Journal of Neurology·Sascha SeidelTill Acker
Jul 17, 2010·Yonsei Medical Journal·Dan Richard LaksHarley Ian Kornblum
Nov 26, 2010·Journal of the National Cancer Institute·Alasdair G RooneyRobin Grant
Jan 8, 2011·BMC Genomics·Xuefeng FangBiaoyang Lin
Feb 24, 2012·Cell Research·Dean G Tang
Mar 21, 2012·Neoplasia : an International Journal for Oncology Research·Muhammad JamalPhilip J Tofilon
Oct 20, 2012·Biochimica Et Biophysica Acta·Alina FilatovaBoyan K Garvalov
Feb 2, 2013·Life Sciences·Luciana Romina Frick, Maximiliano Rapanelli
Feb 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrea SottorivaSimon Tavaré
Sep 21, 2013·Nature·Corbin E Meacham, Sean J Morrison
Oct 25, 2013·Current Opinion in Neurology·Kenneth YanJeremy N Rich
Dec 12, 2013·The Journal of International Medical Research·Wei ShenJie-Sheng Zheng
Jan 5, 2014·Brain Tumor Pathology·Hemragul SabitJun-ichiro Hamada
Mar 13, 2014·Cell Death and Differentiation·B AuffingerA U Ahmed
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Anup Kumar SinghDipak Datta
Nov 19, 2014·Critical Reviews in Oncogenesis·Dinorah Friedmann-Morvinski
Dec 3, 2014·General Hospital Psychiatry·Saliha OzsoyOkan Orhan
Dec 17, 2014·Carcinogenesis·Melanie JacksonAnna Nowak
Jan 7, 2015·Journal of Cellular Biochemistry·Gianfranca MiconiBenedetta Cinque
Mar 10, 2015·Oncotarget·Daniel V BrownTheo Mantamadiotis
May 2, 2015·The American Journal of Psychiatry·Walter A Brown, Maria Rosdolsky
Jun 26, 2015·Genes & Development·Justin D LathiaJeremy N Rich
Jul 3, 2015·Genes & Diseases·Ahmad R SafaKhadijeh Bijangi-Vishehsaraei
Jul 29, 2015·Journal of Neuro-oncology·Jian-tong JiaoJun-fei Shao
Jan 16, 2016·Molecular Neurobiology·Donglai LvJun Xu
Mar 16, 2016·Stem Cells International·Elena CodriciCristiana Tanase
Sep 2, 2016·Oncotarget·Cristina RichichiGiuliana Pelicci
Citations
Mar 10, 2020·Journal of Cellular and Molecular Medicine·Fei-Ting HsuWei-Shu Wang
Jun 25, 2019·Oncotarget·Muhamad N A Kamarudin, Ishwar Parhar
Aug 11, 2018·Neurosurgical Review·Luke MuggeJason Schroeder
Sep 15, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Anna M Bielecka-WajdmanEwa Obuchowicz
Apr 5, 2018·Frontiers in Pharmacology·Sze Kiat TanNagi G Ayad
Oct 13, 2020·Frontiers in Oncology·Zheng HeGang Li
Apr 12, 2021·Briefings in Bioinformatics·Zihao WangWenbin Ma
Jul 14, 2021·Cancer Investigation·Qin XiaLei Dong
Jul 3, 2021·Fundamental & Clinical Pharmacology·Banafshe AbadiHamid-Reza Rahimi