Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor.

ACS Applied Materials & Interfaces
Chao ShiXiaojun Peng


Efficiency of standard chemotherapy is dramatically hindered by intrinsic multidrug resistance (MDR). Recently, to amplify therapeutic efficacy, photodynamic therapy (PDT)-induced mitochondrial dysfunction by decorating targeting moieties on nanocarriers has obtained considerable attention. Nevertheless, low targeting efficiency, complex synthesis routes, and difficulty in releasing contents become the major obstacles in further clinical application. Herein, an ingenious liposomal-based nanomedicine (L@BP) was fabricated by encapsulating a mitochondria-anchored photosensitizer (Cy-Br) and paclitaxel (PTX) for realizing enhanced cooperation therapy. At the cellular level, L@BP could hurdle endosomal traps to localize and implement PDT in mitochondria. Intriguingly, the PDT-induced in situ mitochondrial dysfunction led to intracellular ATP reduction, which triggered the downregulated P-glycoprotein transportation capacity and thus resulted in diminishing the efflux of chemotherapeutic agents and increasing drug uptake by drug-resistant cells. The prepared nanomedicine eminently accumulated in the tumor site and acquired enhanced therapeutic efficiency on PTX-resistant lung cancer cells, which possessed great potential in circumve...Continue Reading


Mar 4, 2000·Advanced Drug Delivery Reviews·M P Murphy, R A Smith
Mar 7, 2006·Nature Reviews. Drug Discovery·Gergely SzakácsMichael M Gottesman
Jul 19, 2008·Science·Brian C Monk, Andre Goffeau
Jan 16, 2010·Nature Reviews. Cancer·Jamie I FletcherMurray D Norris
Jun 28, 2011·International Journal of Pharmaceutics·Niravkumar R PatelVladimir P Torchilin
Sep 4, 2013·Nature Reviews. Clinical Oncology·Elizabeth A KuczynskiRobert S Kerbel
Nov 26, 2013·Advanced Drug Delivery Reviews·Swati Biswas, Vladimir P Torchilin
Sep 7, 2016·ACS Applied Materials & Interfaces·Kai HanHe-You Han
Apr 24, 2017·Advanced Drug Delivery Reviews·Li-Min MuWan-Liang Lu
Mar 15, 2019·Chemical Communications : Chem Comm·Leli ZengHui Chao
Apr 3, 2019·Nano Letters·Wei ChenZhiyong Qian
May 29, 2019·ACS Applied Materials & Interfaces·Peng GaoBo Tang
Jul 13, 2019·Cell·Christian ZierhutHironori Funabiki
Feb 28, 2020·Journal of the American Chemical Society·Mingle LiXiaojun Peng
Mar 3, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Xiaodong ZhangFu-Gen Wu
May 16, 2021·Nature Communications·Emily L GiddingsMercedes Rincon

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