Reversing the curse on PPARγ

The Journal of Clinical Investigation
Mitchell A Lazar

Abstract

Thiazolidinediones (TZDs) are the only antidiabetic drugs that reverse insulin resistance. They have been a valuable asset in the treatment of type 2 diabetes, but their side effects have curtailed widespread use in the clinic. In this issue of the JCI, Kraakman and colleagues provide evidence that deacetylation of the nuclear receptor PPARγ improves the therapeutic index of TZDs. These findings should revitalize the quest to employ insulin sensitization as a first-line approach to managing type 2 diabetes.

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Feb 28, 2017·The Journal of Clinical Investigation·Raymond E SoccioMitchell A Lazar
Apr 4, 2017·The Journal of Clinical Investigation·Mitchell A Lazar
Mar 29, 2018·The Journal of Clinical Investigation·Michael J KraakmanLi Qiang

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Citations

Oct 3, 2019·American Journal of Respiratory Cell and Molecular Biology·Georg HansmannStephen Y Chan
Apr 15, 2020·International Journal of Molecular Sciences·Yujie ShiSiyu Chen
May 25, 2021·Frontiers in Cardiovascular Medicine·Shaying YangTingting Zhou

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Methods Mentioned

BETA
sumoylation
acetylation

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