Reversion by histamine H2-receptor antagonists of plasma membrane alterations in ethanol-induced gastritis

Digestive Diseases and Sciences
Rolando Hernández-Muñoz, F Montiel-Ruíz

Abstract

Ethanol administration rapidly damages surface epithelial cells of rat stomach, leading to altered cellular plasma membranes. Histamine H2-receptor antagonists (H2RA) have been shown to have preventive properties against ethanol-induced gastric mucosal injury. Therefore, the possible reverting properties of H2RA (cimetidine, ranitidine, and famotidine) were tested in ethanol-induced gastritis. Subchronic ethanol administration elicited a histological profile of gastritis and alterations at the plasma membrane level (diminution of some phospholipids, increased cholesterol, and decreased activity of 5'-nucleotidase). H2RA administration to rats with gastritis promptly corrected the ethanol-induced mucosal damage. In addition, cytosolic enzyme activities (alcohol and lactate dehydrogenases) were also modified by gastritis and treatment with H2RA. In conclusion, our data suggest that H2RA improved restitution of the gastric mucosa contributing to the healing process of the gastric damage. The latter indicates reverting properties of H2RA on gastric damage, as well as their cytoprotective effect already described.

References

Dec 1, 1977·The American Journal of Digestive Diseases·R J Biggerstaff, G J Leitch
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Mar 10, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A SlomianyM I Horowitz
Jan 1, 1979·Scandinavian Journal of Gastroenterology·J Deregnaucourt
Apr 27, 1979·Biochimica Et Biophysica Acta·M K WassefM I Horowitz
Mar 30, 1978·Biochimica Et Biophysica Acta·M K WassefM I Horowitz
Aug 1, 1978·Cancer·P Carda-AbellaJ Mate-Jimenez
Apr 1, 1992·Archives of Biochemistry and Biophysics·R Hernández-MuñozV Chagoya de Sánchez
Oct 1, 1992·Archives of Biochemistry and Biophysics·S IncerpiF Schroeder
Oct 1, 1992·Journal of the American College of Nutrition·S RamasamyB Hennig
Dec 1, 1991·Digestive Diseases and Sciences·J CaballeríaC S Lieber
Dec 20, 1990·The New England Journal of Medicine·M Feldman, M E Burton
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·R Hernández-MuñozC S Lieber
Dec 15, 1986·Biochemical Pharmacology·M PasanenU Klotz
Apr 1, 1986·Analytical Biochemistry·E G Loten, J C Redshaw-Loten
Jan 1, 1988·Gastroenterology·P J Oates, J P Hakkinen
Jan 1, 1988·Gastroenterology·W Silen
Jul 1, 1986·Prostaglandins·J L Wallace, B J Whittle
Jan 1, 1985·Annual Review of Physiology·W Silen, S Ito
Feb 1, 1974·The American Journal of Physiology·T J SernkaL L Shanbour
Sep 1, 1974·The American Journal of Digestive Diseases·Y J KuoT J Sernka
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H K SeitzB Kommerell
Mar 18, 1983·Science·L M LichtenbergerB A Hills
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·P ThuluvathE Mezey

❮ Previous
Next ❯

Citations

Jul 3, 2007·Free Radical Biology & Medicine·Laishram Pradeepkumar SinghSnehasikta Swarnakar
Oct 4, 2006·Free Radical Biology & Medicine·Marisela Olguín-MartínezRolando Hernández-Muñoz
Oct 21, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Young JeonHyekyung Ha
Feb 7, 2012·Asian Pacific Journal of Tropical Medicine·Ashish K DasA C Rana
Aug 19, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Hernández-MuñozO Vázquez-Martínez
Mar 11, 2003·Experimental Biology and Medicine·Ileana Hernández-RincónRolando Hernández-Muñoz
Jul 26, 2006·World Journal of Gastroenterology : WJG·Ricardo Vázquez-RamírezRolando Hernández-Muñoz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.