Reversion of muscarinic autoreceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1-13), an endogenous kappa-opioid receptor agonist

British Journal of Pharmacology
M HiramatsuT Kameyama

Abstract

1. We investigated whether carbachol, a muscarinic receptor agonist, induces learning and memory impairment, and if so, dynorphin A (1-13), an endogenous kappa-opioid receptor agonist, ameliorates the impairment of learning and memory induced by carbachol, by use of a step-through type passive avoidance task. 2. Carbachol induced a dose-related dual response. Carbachol (1.66 pmol per rat) administered directly into the hippocampus significantly shortened the step-through latency, while lower (0.166 pmol per rat) and higher (16.6 pmol per rat) doses of carbachol did not induce learning or memory impairment. 3. Dynorphin A (1-13) (0.5 nmol per rat, i.c.v.) administered 5 min after carbachol injection significantly reversed carbachol-induced impairment of learning and memory. 4. Perfusion with carbachol (3 x 10(-4) M) significantly decreased acetylcholine release in the hippocampus during perfusion as determined by in vivo brain microdialysis. This decrease in acetylcholine release was suppressed by co-perfusion with a low dose of atropine (10(-7) M). 5. Dynorphin A (1-13) (0.5 nmol per rat, i.c.v.) immediately before carbachol perfusion completely blocked this decrease in extracellular acetylcholine concentration induced by carba...Continue Reading

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Citations

May 5, 2000·European Journal of Pharmacology·M Hiramatsu, K Inoue
Mar 17, 1999·European Journal of Pharmacology·M Hiramatsu, K Inoue
Apr 14, 2000·Behavioural Brain Research·P M Wall, C Messier
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Dec 12, 2001·British Journal of Pharmacology·T Mamiya, M Ukai
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexander KuzminGeorgy Bakalkin
May 1, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yukihiko ShirayamaRyuzou Kawahara
Aug 18, 2006·Neurobiology of Aging·T YakovlevaG Bakalkin

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