PMID: 7016359Jan 1, 1981Paper

Review: acute versus chronic response to burn injury

Circulatory Shock
R R Wolfe

Abstract

The acute response to burn injury is referred to as the ebb, or shock, phase. It is characterized as a hypodynamic state, with both cardiac output and metabolic rate being depressed. Hyperglycemia is evident, owing both to an increased rate of production of glucose and a peripheral "insulin resistance." Lactate production is markedly elevated, whereas the FFA response is variable. Clinically, the predominant concern is repletion of the plasma volume that was lost as a consequence of increased capillary permeability. If adequate fluid resuscitation is administered, recovery from burn shock can usually be accomplished. The chronic response to burn injury, or flow phase, may last for many weeks. It is a hyperdynamic state, with both cardiac output and metabolic rate being elevated. Without appropriate nutritional therapy, severe protein wasting can occur as a consequence of an accelerated rate of protein catabolism. The increase in protein catabolism is associated with an increase in the rate of glucose production. There appear to be changes in fat metabolism as well, but more quantitative studies are needed in this area. In general, improved emergency room treatment has greatly improved survival from burn shock, and the focus of ...Continue Reading

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

© 2021 Meta ULC. All rights reserved