Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers

Frontiers in Pharmacology
Lisa M FleischerGregory M Miller

Abstract

Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging interest. Here, we review the immunologically-relevant TAAR1 literature and incorporate open-source expression and cancer survival data meta-analyses. We provide strong evidence for TAAR1 expression in the immune system and cancers revealed through NCBI GEO datamining and discuss its regulation in a spectrum of immune cell types as well as in numerous cancers. We discuss connections and logical directions for further study of TAAR1 in immunological function, and its potential role as a mediator or modulator of immune dysregulation, immunological effects of psychostimulant drugs of abuse, and cancer progression.

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Citations

May 22, 2019·Histochemistry and Cell Biology·Mallory S PittsMark D Berry
Oct 30, 2020·Cells·Jesús Cosín-RogerSara Calatayud
Oct 9, 2020·Neuroscience and Biobehavioral Reviews·Seetal DoddMichael Berk
Mar 24, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yue ZhangYun-Ai Su

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Datasets Mentioned

BETA
AL513524.8
GDS6177
132620011
GDS4938
114175011
120320211
GDS4274
GDS4273
96184311
GDS4266

Methods Mentioned

BETA
RNAseq
RNA-seq
biopsy

Software Mentioned

GEO “ Analyze DataSet ”
PROGene
MatInspector
BioXpress
R package RTCGA
EMBL
LASAGNA
ArrayExpress
Analyze Dataset
- Search

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