Review article: a role for gastrointestinal prokinetic agents in the treatment of reflux oesophagitis?

Alimentary Pharmacology & Therapeutics
M Verlinden

Abstract

Gastro-oesophageal reflux disease may result from a host of factors. Medical therapy has largely been aimed at neutralizing acid or decreasing acid production but improvement of upper-gastrointestinal motility may prove to be a valuable treatment modality as well. This paper reviews the current state of knowledge of the pathogenesis of reflux disease and concentrates upon promotility treatment with domperidone, metoclopramide and cisapride.

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