PMID: 11929385Apr 4, 2002Paper

Review article: an approach to Helicobacter pylori infection in the elderly

Alimentary Pharmacology & Therapeutics
Alberto Pilotto, P Malfertheiner

Abstract

The prevalence of Helicobacter pylori infection increases with age world-wide, reaching levels of 40-60% in asymptomatic elderly subjects and over 70% in elderly patients with gastroduodenal diseases. However, the percentage of H. pylori-positive elderly patients who are treated for their infection remains very low. Data are now available that demonstrate the benefit of curing H. pylori infection in elderly patients with H. pylori-associated peptic ulcer disease and severe chronic gastritis. Furthermore, the cure of H. pylori may prevent the progression of intestinal metaplasia and gastric atrophy. New studies are needed to clarify the role of eradication in elderly patients with non-ulcer dyspepsia and gastro-oesophageal reflux disease and in those who use non-steroidal anti-inflammatory drugs. H. pylori infection may be easily diagnosed by histological evaluation, rapid urease test or culture performed on gastric biopsies taken during endoscopy. However, the biopsy site must be carefully selected in elderly patients. For non-invasive monitoring of H. pylori infection after treatment, the 13C-urea breath test has significantly higher accuracy than serology in the elderly; further studies are needed to clarify the role of the H...Continue Reading

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Citations

Aug 29, 2002·Helicobacter·Alberto Pilotto, Nathalie Salles
Jan 5, 2005·Digestive Diseases and Sciences·Yaron NivRivka Koren
Dec 25, 2008·Glycobiology·Halina Miller-PodrazaKarl-Anders Karlsson
Jun 17, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alberto PilottoUNKNOWN IPOD Investigators
Oct 14, 2006·Journal of the American Geriatrics Society·Alberto PilottoFrancesco Di Mario
Jun 30, 2010·Drugs & Aging·Alberto PilottoDaniele Sancarlo
Oct 5, 2007·Expert Review of Anti-infective Therapy·Nathalie Salles, Francis Mégraud
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Nov 14, 2003·Journal of Medical Microbiology·Lyudmila BoyanovaZacharii Krastev
Feb 23, 2019·Canadian Journal of Gastroenterology & Hepatology·Igor DumicTamara Milovanovic
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Koichiro WatanabeToshio Fujioka
Apr 18, 2021·Emergency Medicine Clinics of North America·Ryan Spangler, Sara Manning
May 28, 2004·Ageing Research Reviews·Kevin P High
Jun 18, 2021·Frontiers in Immunology·Lynn van OlstHelga E de Vries

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