PMID: 8971278Dec 1, 1996Paper

Review article: antibiotic-induced Clostridium difficile infection

Alimentary Pharmacology & Therapeutics
C D Settle, M H Wilcox

Abstract

The great majority of cases of Clostridium difficile infection are hospital-acquired, and the reported incidence in England and Wales has increased sixfold between 1990 and 1993, with at least 17 patients dying in a recent large nosocomial outbreak. C. difficile infection accounts for an average 3-week increased length of stay in hospital. Acquisition of a toxigenic strain of Clostridium difficile may be followed by asymptomatic carriage, diarrhoea, colitis or pseudomembranous colitis. Antibiotic treatment and older age are major risk factors for the development of symptomatic disease, but less well-defined differences in strain virulence and host susceptibility are also probably important. Accurate data on the relative risks of different antibiotics to induce symptomatic C. difficile infection are scarce, but third-generation cephalosporins are frequently implicated. New kits are becoming available for the laboratory diagnosis of C. difficile infection but many of these lack sensitivity. Oral metronidazole or vancomycin are the main treatment options but avoidance of further antibiotics should also be encouraged where possible. The role of environmental C. difficile spores, which are highly resistant to conventional disinfecta...Continue Reading

Citations

Feb 4, 1999·Clinical Cardiology·J S Muchnick, J L Mehta
Nov 5, 2003·Gastrointestinal Endoscopy·Pascal PerneyFrançois Blanc
Mar 5, 2009·The Journal of Antimicrobial Chemotherapy·Ian A CritchleyUrs A Ochsner
Oct 1, 1997·Journal of Clinical Pharmacy and Therapeutics·H A HalimA K Ott
Nov 6, 2010·Science·Bret D WallaceMatthew R Redinbo
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·C G DinizM A De Carvalho
Aug 5, 2003·QJM : Monthly Journal of the Association of Physicians·M B Frenz, A S McIntyre
Nov 8, 2007·Digestive Diseases and Sciences·Crystianne Calado LimaJosé Henrique Leal-Cardoso
Dec 4, 1998·American Journal of Infection Control·A B ZafarP A Mennonna
Aug 16, 2005·The Journal of Hospital Infection·K R Banfield, K G Kerr
Jul 22, 1998·The American Journal of Gastroenterology·A NawazC Pellecchia
May 14, 2017·The Journal of Experimental Medicine·Jean-Nicolas SchickelEric Meffre
Mar 27, 2003·Alimentary Pharmacology & Therapeutics·L BeaugerieUNKNOWN Study Group
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·D E MahonyH Maguire
Mar 1, 1997·Baillière's Clinical Gastroenterology·K LeiperJ M Rhodes

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