PMID: 8971281Dec 1, 1996Paper

Review article: beta 3-adrenoceptor agonists--future anti-inflammatory drugs for the gastrointestinal tract?

Alimentary Pharmacology & Therapeutics
A Anthony

Abstract

The beta 3-adrenoceptor is now a recognized sub-type of beta-adrenoceptor and is the principle adrenoceptor responsible for lipolysis in rat adipocytes. The receptor is also found in the gastrointestinal tract where beta 3-adrenoceptor agonists are both spasmolytic and potent inhibitors of experimental non-steroidal anti-inflammatory drug (NSAID)-induced gastric and small intestinal ulcers. There is evidence to suggest that the underlying mechanism of protection involves enhancement of mucosal blood flow, possibly as a result of relaxation of vascular and non-vascular smooth muscle. This review examines some possible therapeutic applications for beta 3-adrenoceptor agonists in ulcero-inflammatory disorders of the gastrointestinal tract where an altered blood flow state is a component of the underlying pathogenic process.

Citations

Jul 25, 1998·Alimentary Pharmacology & Therapeutics·A AnthonyA J Wakefield
May 3, 2000·Alimentary Pharmacology & Therapeutics·A AnthonyA J Wakefield
Mar 13, 2001·Japanese Journal of Pharmacology·T Horinouchi, K Koike
Sep 1, 2004·American Journal of Veterinary Research·Mireille MeylanAdrian Steiner
May 5, 2000·Medicine and Science in Sports and Exercise·D MatthysJ L Pannier
Sep 20, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roland SeilerBruno M Balsiger
Sep 29, 1998·The Journal of Pharmacy and Pharmacology·A Díez-SampedroA Barber
Mar 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mohamed A MotagallyAlan E Lomax
Dec 6, 2005·European Journal of Pharmacology·Paul SchaefferJean-Marc Herbert
Apr 27, 2010·Molecular and Cellular Endocrinology·Zhen PangH Gregory Polites

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