Review article: bugs, inflammation and mood-a microbiota-based approach to psychiatric symptoms in inflammatory bowel diseases

Alimentary Pharmacology & Therapeutics
Anne K ThomannSiew C Ng

Abstract

Psychiatric co-morbidities including depression and anxiety are common in inflammatory bowel diseases (IBD). Emerging evidence suggests that interactions between the gut microbiota and brain may play a role in the pathogenesis of psychiatric symptoms in IBD. To review the literature on microbiota-brain-gut interactions in gut inflammation, psychosocial stress and mental disorders and to discuss the putative mediating role of gut microbiota in the development of psychiatric symptoms or co-morbidities in IBD. A literature search was conducted on Ovid and Pubmed to select relevant animal and human studies reporting an association between IBD, mental disorders and gut microbiota. Gut microbial alterations are frequently reported in subjects with IBD and with mental disorders. Both have been associated with reduced faecal bacterial diversity, decreased taxa within the phylum Firmicutes and increased Gammaproteobacteria. In animal studies, microbial perturbations induce behavioural changes and modulate inflammation in mice. Anxiety- and depression-like behaviours in animals can be transferred via faecal microbiota. In humans, modulation of the gut microbiota with probiotics is associated with behavioural and mood changes. Recent data...Continue Reading

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Citations

Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haley A VecchiarelliMatthew N Hill
Oct 5, 2020·The Lancet. Gastroenterology & Hepatology·Hans Strid
Jan 28, 2021·Journal of Clinical Medicine·Spyros PeppasStefanos Bonovas
Mar 23, 2021·Gastroenterology Research and Practice·Ashley M SidebottomDavid T Rubin
Jul 18, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sijing DongSicen Wang
Nov 4, 2021·International Journal of Colorectal Disease·Zahid Ijaz TararYezaz A Ghouri

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