Review article: Environmental heatstroke and long-term clinical neurological outcomes: A literature review of case reports and case series 2000-2016

Emergency Medicine Australasia : EMA
Emily M LawtonGenevieve M Gabb

Abstract

Global temperatures are rising; extreme environmental heat can result in adverse health effects including heatstroke. Acute effects of heat are well recognised, but there is less understanding of potential long-term adverse outcomes. Our aim was to review recent medical literature for clinical cases of environmental heatstroke with a focus on neurological outcome. Structured search strategies were designed to retrieve publications of heatstroke case reports using Ovid Medline and Embase (2000-2016). One thousand and forty-nine abstracts were identified, and after application of exclusion criteria 71 articles deemed relevant. Ninety cases were identified from 71 articles. 100% presented with acute neurological symptoms; 87.8% presented with non-neurological symptoms. 44.4% patients recovered fully, 23.3% died, 23.3% suffered convalescent or long-term neurological sequelae, and in 8.9% no long-term follow up was available. 57.1% of the patients who died or had a neurological deficit had no documented co-morbidity. Patterns of neurological deficits included 66.7% patients with motor dysfunction, 9.5% cognitive impairment, 19% both motor and cognitive impairment and 4.7% other. In total 71.4% of the impaired patients had long-term ...Continue Reading

References

Aug 8, 1998·Annals of Internal Medicine·J E DematteI M Ndukwu
Jun 21, 2002·The New England Journal of Medicine·Abderrezak Bouchama, James P Knochel
Oct 29, 2005·Journal of Neuropathology and Experimental Neurology·Céline BazilleFrançoise Gray
Aug 19, 2007·Archives of Internal Medicine·Laurent ArgaudDominique Robert
May 1, 2009·Intensive Care Medicine·Sebastian PeaseMichel Wolff
Sep 17, 2015·The New England Journal of Medicine·Christopher J L Murray
Jul 15, 2016·Critical Care : the Official Journal of the Critical Care Forum·Edward James Walter, Mike Carraretto
Nov 27, 2016·Critical Care : the Official Journal of the Critical Care Forum·Guy W GloverNiklas Nielsen
Jan 28, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Brian C DavisUNKNOWN Acute Liver Failure Study Group

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