Review article: gut flora and inflammatory bowel disease

Alimentary Pharmacology & Therapeutics
P MarteauP Seksik

Abstract

The pathogenesis of inflammatory bowel disease involves interactions between the host susceptibility, mucosal immunity and intestinal microflora. There is therefore great interest in the changes in the endogenous flora in inflammatory bowel disease patients and in the establishment of potential genetic variations in host responses to endogenous bacteria. In this review, we summarize the modifications in the various regional ecosystems in the gastrointestinal tract during inflammatory bowel disease (luminal bacteria in faeces or inside the gastrointestinal tract, bacteria in mucus and bacteria directly attached to the mucosa). Results were obtained following a 'candidate microorganism strategy' and, as is occurring increasingly frequently, following a 'full description strategy', which has progressed largely due to the development of culture-independent techniques. The possibility of modifying the ecosystem using prebiotics or probiotics offers hope for new treatment developments, particularly in the prevention of relapse.

References

Dec 1, 1978·Gut·M R KeighleyJ Alexander-Williams
Nov 1, 1988·Scandinavian Journal of Gastroenterology·J P Van de MerweM P Hazenberg
Jun 1, 1983·Antonie van Leeuwenhoek·J G Ruseler-van Embden, H C Both-Patoir
Apr 1, 1997·Digestive Diseases and Sciences·C FavierJ Mizon
Dec 3, 1998·Gastroenterology·A Darfeuille-MichaudJ F Colombel
May 2, 2000·Applied and Environmental Microbiology·A SghirJ Dore
Aug 29, 2000·Digestive Diseases and Sciences·M GuslandiP A Testoni
Sep 26, 2001·Applied and Environmental Microbiology·P MarteauG Corthier
Jan 10, 2002·Gastroenterology·Alexander SwidsinskiHerbert Lochs
May 11, 2002·The American Journal of Gastroenterology·Christel NeutJean-Fredéric Colombel
Jun 29, 2002·The British Journal of Nutrition·M BlautW de Vos
Jul 13, 2002·European Journal of Immunology·Florian ObermeierWerner Falk
Oct 11, 2002·Scandinavian Journal of Gastroenterology·B KleessenM Blaut
Oct 26, 2002·International Journal of Medical Microbiology : IJMM·Arlette Darfeuille-Michaud
Feb 6, 2003·Journal of the American College of Nutrition·Hideki IshikawaToru Otani
Mar 6, 2003·Best Practice & Research. Clinical Gastroenterology·Philippe MarteauFergus Shanahan
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Philippe Marteau, Fergus Shanahan
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Francisco Guarner, Juan-R Malagelada
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Cyrus P TamboliPierre Desreumaux
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Paolo GionchettiMassimo Campieri
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Lothar Steidler

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Citations

May 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Francisco GuarnerGraham A W Rook
Sep 17, 2005·Animal Health Research Reviews·G M NavaM P Castañeda
Jul 25, 2006·Infection and Immunity·Kenneth W SimpsonYnte H Schukken
Nov 8, 2005·Journal of Clinical Microbiology·M F De La CochetièreJ Doré
Oct 28, 2006·Postgraduate Medical Journal·Milan LukasZdenek Maratka
Feb 2, 2013·Gut Pathogens·Shirajum MoniraMunirul Alam
Feb 2, 2008·World Journal of Gastroenterology : WJG·Gert De HertoghKarel Geboes
Apr 28, 2012·Digestive Diseases and Sciences·Manami HinataKouhei Fukushima
Jan 10, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·P H E TeeuwenR P Bleichrodt
Nov 28, 2013·Journal of Clinical Gastroenterology·Qiurong LiJieshou Li
Oct 25, 2007·Digestive Diseases and Sciences·Keiko KataokaYoshinari Ohnishi
Jun 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Trishna DebnathBeong Ou Lim
May 6, 2008·International Journal of Food Microbiology·Shanthi G ParkarMargot A Skinner
Jul 16, 2009·Environmental Microbiology·Julien TapMarion Leclerc
May 25, 2010·Journal of Clinical Nursing·Virginia A Cary, Joseph Boullata
Nov 1, 2006·IEEE Transactions on Bio-medical Engineering·Erik A JohannessenJon M Cooper
Jun 22, 2005·International Journal of Antimicrobial Agents·Susan F PlummerJohn Hunter
Mar 15, 2015·Gastroenterología y hepatología·José F García-MazcorroJosé L Tamayo
Nov 11, 2008·The Lancet Infectious Diseases·Anne-Marie LoweMarcel A Behr
Jan 25, 2006·Inflammatory Bowel Diseases·Harry SokolJoël Doré
Aug 4, 2009·Gastroenterología y hepatología·Paloma Sánchez-Fayos CalabuigJuan Carlos Porres Cubero
Jul 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Tomasz GosiewskiPiotr B Heczko
Mar 18, 2008·The American Journal of Gastroenterology·Cristina MartinezJuan-R Malagelada
May 22, 2008·Journal of Pediatric Gastroenterology and Nutrition·Andrew R BarclayLawrence T Weaver
May 16, 2006·Digestive Diseases·Philippe Marteau
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vicky De PreterKristin Verbeke
Mar 1, 2008·Expert Review of Clinical Immunology·Belgin Dogan, Kenneth W Simpson
Feb 22, 2017·Annals of Neurology·Helen TremlettEmmanuelle Waubant

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