Review article: lymphatic system and associated adipose tissue in the development of inflammatory bowel disease

Alimentary Pharmacology & Therapeutics
P-Y von der Weid, K J Rainey

Abstract

The lymphatic system plays critical roles in tissue fluid homoeostasis, immune defence and metabolic maintenance. Lymphatic vessels transport lymph, proteins, immune cells and digested lipids, allowing fluid and proteins to be returned to the blood stream, lipids to be stored and metabolized and antigens to be sampled in lymph nodes. Lymphatic drainage is mainly driven by rhythmic constrictions intrinsic to the vessels and critically modulated by fluid pressure and inflammatory mediators. To collect and discuss the compelling available information linking the lymphatic system, adiposity and inflammation. A literature search was performed through PubMed focusing on lymphatic system, inflammation, immune cells and fat transport and function in the context of IBD. Evidence collected allows us to propose the following working model. Compromised lymph drainage, reported in IBD, leads to oedema, lymphangiogenesis, impaired immune cell trafficking and lymph leakage. Lymph factor(s) stimulate adipose tissue to proliferate and produce cytokines, which affect immune cell functions and exacerbate inflammation. Understanding the lymphatic system's role in immune cell trafficking and immune responses, contribution to fat transport, distribu...Continue Reading

References

Apr 1, 1977·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·S G Turner, J A Barrowman
Aug 14, 1976·The Veterinary Record·D M BainesD A Eichler
Apr 1, 1992·The Journal of Surgical Research·M K Ferguson
Sep 1, 1992·The British Journal of Surgery·A L SheehanN A Shepherd
Mar 1, 1973·The Journal of Physiology·H J Mawhinney, I C Roddie
Oct 1, 1981·American Journal of Clinical Pathology·J KoviC T Hoang
Jun 23, 1984·British Medical Journal·C O'MoráinA J Levi
May 1, 1983·The Journal of Physiology·N G McHale, I C Roddie
Sep 24, 1981·Nature·M G Johnston, J L Gordon
Jan 1, 1980·Human Genetics·Z PapZ Papp
Jan 1, 1980·Digestion·R V HeatleyE W Owen
Apr 1, 1995·Journal of Clinical Pathology·E E MooneyD O Hourihane
Jan 1, 1994·Advances in Experimental Medicine and Biology·H J RothkötterR Pabst
Jun 1, 1994·The Journal of Surgical Research·L B ReederM K Ferguson
Sep 1, 1995·Clinics in Dermatology·T J Ryan
Apr 1, 1996·The Journal of Experimental Medicine·A KratzN H Ruddle
Jun 1, 1996·The Journal of Physiology·P Y von der WeidD F Van Helden
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Apr 16, 1998·The Journal of Investigative Dermatology·G WeinlichN Romani
Jun 12, 1998·Journal of Surgical Oncology·M L Salgaller, P A Lodge
Oct 31, 1998·Vascular Medicine·A Szuba, S G Rockson
Dec 5, 1998·Canadian Journal of Physiology and Pharmacology·J B Hay, W N Andrade
Mar 17, 1999·Annals of Surgery·S A SlavinR K Jain
Jun 26, 1999·Gastroenterology·P DesreumauxJ F Colombel

❮ Previous
Next ❯

Citations

Jun 19, 2001·Biochimica Et Biophysica Acta·V A Smits, R H Medema
May 28, 2003·European Journal of Medicinal Chemistry·Dong Chan KimKyung Ho Yoo
Jun 7, 1997·Biochimica Et Biophysica Acta·L Wolff
Dec 31, 2011·The Journal of Biological Chemistry·Tenagne Delessa ChallaChristian Wolfrum
Sep 13, 2013·Lymphatic Research and Biology·Shan Liao, Timothy P Padera
May 6, 2011·Current Opinion in Gastroenterology·Pierre-Yves von der WeidJosé Gp Ferraz
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Scott D ZawiejaMariappan Muthuchamy
Mar 13, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie Berthelot, Pascal Claudepierre
Dec 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Cristina T KeslerTimothy P Padera
Dec 15, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sanjukta ChakrabortyMariappan Muthuchamy
Mar 20, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Kotaro SuehiroKimikazu Hamano
Mar 10, 2015·Ultrasound in Medicine & Biology·Kotaro SuehiroKimikazu Hamano
Jan 27, 2015·Seminars in Cell & Developmental Biology·Sanjukta ChakrabortyMariappan Muthuchamy
Nov 5, 2016·Immunology·Sandeep Sundara Rajan, Maria Paula Longhi
Dec 7, 2016·Journal of Vascular Research·Valerio CicconeLucia Morbidelli
Jun 29, 2017·Nature Reviews. Gastroenterology & Hepatology·Jeremiah Bernier-Latmani, Tatiana V Petrova
May 16, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yujia LinShan Liao
Jun 28, 2018·Journal of Crohn's & Colitis·Weisong ShenWeiming Zhu
Feb 10, 2018·Cell and Tissue Research·Matthew Stephens, Shan Liao
Oct 6, 2019·Heart·Niklas Telinius, Vibeke Elisabeth Hjortdal
Nov 30, 2019·Cell and Tissue Research·Patricia de Albuquerque Garcia RedondoRadovan Borojevic
Sep 3, 2014·Physiology·Daniel Konrad, Stephan Wueest
Jan 1, 2016·Expert Review of Endocrinology & Metabolism·Darlene E BerrymanJohn J Kopchick
Mar 6, 2018·Expert Opinion on Drug Delivery·Antonella ObinuPaolo Giunchedi
Jun 13, 2018·Journal of Clinical Medicine·Abdurrahman SahinIbrahim Halil Bahcecioglu
Oct 10, 2018·Frontiers in Cellular and Infection Microbiology·Guillaume Le BautAnne Dumay
Oct 9, 2018·Inflammatory Bowel Diseases·Weisong ShenWeiming Zhu
Mar 28, 2017·Experimental Biology and Medicine·Gabriella R AbouelkheirJoseph M Rutkowski
Jul 26, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yi LiJieshou Li
Mar 5, 2018·Physiology & Behavior·Aaron M MagnusonMichelle T Foster
Mar 19, 2019·Journal of Pediatric Surgery·Emily J OnuferBrad W Warner
May 1, 2021·International Journal of Molecular Sciences·Eva KaraskovaDavid Karasek
May 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lu ZhangFei Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.