Abstract
Crohn's disease is a chronic, debilitating subset of inflammatory bowel diseases, which may affect any part of the gastrointestinal tract. The most common sites of inflammation are the terminal ileum and/or the colon. Fistulous disease is present in up to 20% of patients, particularly in those having rectal involvement. The aetiology of Crohn's disease still remains obscure, therefore medical therapy is directed towards symptomatic relief in active disease and relapse prevention in the long-term setting. Contemporary Crohn's disease management comprises individual treatment depending mainly on Crohn's disease localization in the gastrointestinal tract and the disease severity. The mainstay of current medical treatment for mild to moderately active stages of Crohn's disease includes aminosalicylates, antibiotics, glucococorticosteroids and immunomodulators. Biologics such as anti TNF-compounds and anti-integrins are being introduced.
References
Sep 1, 1991·Gut·L SutherlandM Kelly
Apr 1, 1990·Gastroenterology·R ModiglianiE Rene
Feb 2, 1995·The New England Journal of Medicine·B G FeaganM Hopkins
Dec 1, 1994·Journal of Clinical Gastroenterology·W J TremaineA R Zinsmeister
Sep 29, 1994·The New England Journal of Medicine·G R GreenbergT Persson
Sep 29, 1994·The New England Journal of Medicine·P RutgeertsH Lorenz-Meyer
Aug 1, 1993·Gastroenterology·K EweK H Meyer zum Büschenfelde
Nov 1, 1995·Gut·S CandyR Goodman
Aug 1, 1997·Gut·M CampieriL G Nilsson
Oct 9, 1997·The New England Journal of Medicine·S R TarganP J Rutgeerts
Aug 6, 1998·The New England Journal of Medicine·O O ThomsenE Pettersson
May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Aug 28, 1999·Gastroenterology·W J SandbornR H Murdock
Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·T H FlorinT Persson
Jun 27, 2000·Gastroenterology·B E Sands
Oct 7, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·P Rutgeerts
Apr 21, 2001·Gastroenterology·W J SandbornUNKNOWN CDP571 Crohn's Disease Study Group
Citations
Mar 24, 2007·Diseases of the Colon and Rectum·Christopher M ByrneJames D Harrison
Mar 12, 2004·The Journal of Surgical Research·Fabrizio Michelassi, Gaurav A Upadhyay
Mar 9, 2004·Peptides·Bariş CakirBerrak C Yeğen
Feb 6, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jin LiJing Wang
Mar 3, 2010·World Journal of Surgery·Michael F CunninghamP Ronan O'Connell
Jan 17, 2008·Drug Delivery·Heejung KimYoung Mi Kim
Apr 11, 2008·Journal of Pharmaceutical Sciences·Heejung KimYunjin Jung
Apr 9, 2005·Alimentary Pharmacology & Therapeutics·G J JohnsonJ C Mansfield
Apr 27, 2016·Molecular Pharmaceutics·Wooseong KimYunjin Jung
May 23, 2015·BMC Complementary and Alternative Medicine·Kurexi YunusiHalmurat Upur
May 22, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael F CunninghamP Ronan O'Connell
Oct 13, 2006·World Journal of Gastroenterology : WJG·A A van Bodegraven, Chris J J Mulder
Nov 15, 2018·Drug Delivery and Translational Research·Dohoon KimYunjin Jung
Nov 20, 2019·Molecular Pharmaceutics·Seongkeun JeongYunjin Jung
Aug 7, 2019·Molecular Pharmaceutics·Wooseong KimYunjin Jung