Review article: The measurement of non-acid gastro-oesophageal reflux

Alimentary Pharmacology & Therapeutics
A J Smout

Abstract

Oesophageal pH monitoring has been used for three decades to study gastro-oesophageal reflux, but it does not allow detection of non-acid reflux episodes. To discuss the techniques by which non-acid reflux can be measured and to evaluate the clinical relevance of such measurements. Review of the literature on non-acid reflux monitoring. Ambulatory oesophageal impedance monitoring (using a catheter with ring electrodes) allows one to detect all types of gastro-oesophageal reflux, acid as well as non-acid. Measurement of intra-oesophageal bilirubin concentration also detects reflux irrespective of the pH, but only when there is bilirubin in the gastric juice and technical short-comings limit the applicability of this technique. In untreated subjects, about 50% of reflux episodes are non-acid (nadir pH > 4). In patients on acid inhibition, up to 95% of reflux episodes are non-acid. Treatment with an acid inhibitor leads to a significant decrease in the incidence of acid reflux episodes, but not to a reduction in the total number of reflux episodes. This shift is associated with a shift in symptoms from heartburn to regurgitation. With impedance monitoring, the temporal association between symptoms that persist during inhibition of...Continue Reading

References

Aug 27, 2005·Gut·A J BredenoordA J P M Smout
Nov 8, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ikuo HiranoPeter J Kahrilas
Nov 24, 2005·Alimentary Pharmacology & Therapeutics·P J Kahrilas, J E Pandolfino
Feb 17, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
May 12, 2006·World Journal of Gastroenterology : WJG·Stanislas Bruley des VarannesJean Paul Galmiche
Jul 20, 2006·The American Journal of Gastroenterology·Frank ZerbibDaniel Sifrim
Aug 11, 2006·Chest·Radu TutuianDonald O Castell
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S RomanUNKNOWN Consortium de Recherche Indépendant sur le Traitement et l'Exploration du Reflux gastro-oesophagien et de l'Endobrachyoesoph
Feb 14, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amine HilaDonald O Castell

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Citations

Jan 1, 2008·Gastroenterology Research and Practice·C Shekhar, P J Whorwell
Jun 19, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E SavarinoV Savarino
Jul 12, 2020·Current Gastroenterology Reports·Thomas A Zikos, John O Clarke
Oct 1, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Milena NikolicSebastian F Schoppmann

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