Review: association between angiotensin converting enzyme G2350A polymorphism and hypertension risk: a meta-analysis

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Wenquan Niu Dingliang Zhu

Abstract

An exonic polymorphism G2350A (rs4343) in angiotensin converting enzyme (protein: ACE; gene: ACE) was shown to exert the most significant influence on plasma ACE levels. We therefore performed a meta-analysis to investigate association of ACE G2350A polymorphism with hypertension. Published case-control studies in English were identified. A total of four studies with 1699 cases and 1274 controls were identified. A random-effects model was performed irrespective of the between-study heterogeneity. Study quality was assessed in duplicate. Compared with 2350G, the ACE 2350A allele conferred a protective effect on hypertension (odds ratio (OR) = 0.81; 95% confidence interval (CI), 0.56-1.18; p = .28). Similarly, comparisons of 2350AA and 2350GA with 2350GG generated a nonsignificant reduced risk, respectively. Under the dominant model, the ACE 2350A allele conferred a reduced hypertension risk and such associations were divergent between Han Chinese and Muslims from the Arab Gulf and Pakistan. Under the recessive model, this protective effect was totally reversed (OR = 1.01; 95% CI, 0.77-1.33; p = .94). Subgroup analyses indicated a significant protective effect of ACE 2350A compared with 2350G among Muslims from the Arab Gulf and ...Continue Reading

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Citations

Feb 10, 2011·International Archives of Occupational and Environmental Health·Syed Kashif Nawaz, Shahida Hasnain
May 27, 2014·BioMed Research International·Kh Dhanachandra SinghMuthusamy Karthikeyan
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May 25, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Jun WangHui-Jun Mu
Aug 3, 2016·The Journal of Clinical Hypertension·Moran Blaychfeld-MagnaziTaiba Zornitzki
Nov 28, 2017·Clinical and Experimental Hypertension : CHE·Feifei SunChangchun Qiu
Oct 31, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nan WangJianYou Li

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