Review: Biological relevance of disseminated tumor cells in cancer patients

International Journal of Cancer. Journal International Du Cancer
Sabine RiethdorfKlaus Pantel

Abstract

The prognosis of cancer patients is largely determined by the occurrence of distant metastases. In patients with primary tumors, this relapse is mainly due to clinically occult micrometastasis present in secondary organs at primary diagnosis but not detectable even with high resolution imaging procedures. Sensitive and specific immunocytochemical and molecular assays enable the detection and characterization of disseminated tumor cells (DTC) at the single cell level in bone marrow (BM) as the common homing site of DTC and circulating tumor cells (CTC) in peripheral blood. Because of the high variability of results in DTC and CTC detection, there is an urgent need for standardized methods. In this review, we will focus on BM and present currently available methods for the detection and characterization of DTC. Furthermore, we will discuss data on the biology of DTC and the clinical relevance of DTC detection. While the prognostic impact of DTC in BM has clearly been shown for primary breast cancer patients, less is known about the clinical relevance of DTC in patients with other carcinomas. Current findings suggest that DTC are capable to survive chemotherapy and persist in a dormant nonproliferating state over years. To what ex...Continue Reading

References

Nov 21, 1992·Lancet·H SillyM Wilders-Truschnig
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SchlimokG Riethmüller
Oct 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J CoteM P Osborne
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G SchlimokG Riethmüller
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K PantelM W Köllermann
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M GerhardM Neumaier
Jun 29, 1995·The New England Journal of Medicine·R D EnnisL D Wilson
Sep 1, 1993·Journal of the National Cancer Institute·K PantelG Riethmüller
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·K PantelM W Köllermann
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ZippeliusK Pantel
Aug 1, 1997·The Annals of Thoracic Surgery·A OhgamiK Yasumoto
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A SchoenfeldR C Coombes
Dec 13, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D P Wood, M Banerjee
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S BraunK Pantel
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B M SmithR C Coombes
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N BeroisE Osinaga

❮ Previous
Next ❯

Citations

Jan 15, 2013·Cancer Immunology, Immunotherapy : CII·Tobias M Gorges, Klaus Pantel
Feb 22, 2012·Langenbeck's Archives of Surgery·Gunnar SteinertJürgen Weitz
Sep 7, 2011·Breast Cancer Research and Treatment·Brant PohorelicA Magliocco
Mar 5, 2009·Cancer Metastasis Reviews·Malin Sund, Raghu Kalluri
May 8, 2010·Journal of Mammary Gland Biology and Neoplasia·Arnaud BonnometChristine Gilles
Jun 1, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Kai BartkowiakKlaus Pantel
Jul 24, 2012·Nano Letters·Marisa Maltez-da CostaArben Merkoçi
Dec 11, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christopher Y ParkIrving L Weissman
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
Mar 25, 2009·Nature Reviews. Cancer·Christoph A Klein
Feb 6, 2013·Nature Reviews. Clinical Oncology·François-Clément BidardJean Paul Thiery
Jun 2, 2012·Nature Reviews. Drug Discovery·Bedrich L EckhardtRobin L Anderson
Jul 11, 2012·Nature Reviews. Urology·David SchillingArnulf Stenzl
May 19, 2010·Lab on a Chip·Nastaran HashemiFrances S Ligler
Dec 14, 2011·The Cancer Journal·Daniel C DanilaHoward I Scher
Apr 15, 2010·Thorax·Michael R Loebinger, Sam M Janes
Jun 13, 2012·International Journal of Hepatology·Franck Chiappini
May 14, 2009·Cancer Research·Michael R LoebingerSam M Janes
Feb 19, 2013·BMC Molecular Biology·Christopher J WeltyColm Morrissey
Oct 20, 2010·BMC Medical Imaging·Aristarchos PapagiannarosVladimir Torchilin
Dec 19, 2008·Breast Cancer Research : BCR·Ann F Chambers, Paul E Goss
Jan 20, 2010·Breast Cancer Research : BCR·Sabine Riethdorf, Klaus Pantel
Jan 28, 2014·PloS One·Zbigniew T CzyżChristoph A Klein
Jun 11, 2011·Biomarkers in Medicine·Jeffrey S Ross
Nov 17, 2012·Archives of Pathology & Laboratory Medicine·Mark PodberezinChung-Che Jeff Chang
Aug 2, 2014·PloS One·Claire M WolfromJean Deschatrette
Jan 5, 2014·Stem Cells International·Bernadette BibberPranela Rameshwar
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael J MitchellMichael R King

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Catherine Alix-PanabièresKlaus Pantel
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Harriet WikmanKlaus Pantel
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Francois-Clément BidardInstitut Curie Breast Cancer Study Group
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Volkmar MullerKlaus Pantel
© 2022 Meta ULC. All rights reserved