Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies

The Journal of Clinical Endocrinology and Metabolism
Nectaria Xita, Agathocles Tsatsoulis

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder of premenopausal women, characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance and abdominal obesity as frequent metabolic traits. Although PCOS manifests clinically during adolescence, emerging data suggest that the natural history of PCOS may originate in intrauterine life. Evidence from experimental, clinical, and genetic research supporting the hypothesis for the fetal origins of PCOS has been analyzed. Female primates, exposed in utero to androgen excess, exhibit the phenotypic features of PCOS during adult life. Clinical observations also support a potential fetal origin of PCOS. Women with fetal androgen excess disorders, including congenital 21-hydroxylase deficiency and congenital adrenal virilizing tumors, develop features characteristic of PCOS during adulthood despite the normalization of androgen excess after birth. The potential mechanisms of fetal androgen excess leading to a PCOS phenotype in humans are not clearly understood. However, maternal and/or fetal hyperandrogenism can provide a plausible mechanism for fetal programing of PCOS, and this, in part, may be genetically determined. Thus, gene...Continue Reading

Citations

Feb 22, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fan QuHe-Feng Huang
Aug 30, 2008·Reviews in Endocrine & Metabolic Disorders·Lourdes IbáñezMaria Victoria Marcos
Oct 14, 2010·Metabolic Syndrome and Related Disorders·Andrew A Bremer
Dec 20, 2008·Human Reproduction·Benedito Borges da SilvaJosé Antônio Gontijo
Oct 22, 2010·Human Reproduction Update·Deborah M SlobodaRoger Hart
Sep 8, 2011·Human Reproduction Update·UNKNOWN Evian Annual Reproduction (EVAR) Workshop Group 2010C M Howles
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology·Marie Nam Menke, Jerome F Strauss
Jan 12, 2008·Menopause : the Journal of the North American Menopause Society·Maria AlevizakiIoannis Georgiou
Jun 30, 2011·Menopause : the Journal of the North American Menopause Society·Katerina SaltikiMaria Alevizaki
Feb 17, 2007·Clinical Obstetrics and Gynecology·Marie Nam Menke, Jerome F Strauss
Jun 12, 2008·American Journal of Physiology. Endocrinology and Metabolism·Marek DemissieJon E Levine
Feb 11, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·T Rhen, A Schroeder
Aug 5, 2011·Reproductive Biology and Endocrinology : RB&E·Kunju SathishkumarChandra Yallampalli
Feb 10, 2011·Endocrinology·Kazunari NoharaFranck Mauvais-Jarvis
Feb 22, 2013·The Journal of Endocrinology·Xiaonan YanJiayin Liu
Oct 3, 2013·The Journal of Endocrinology·Kazunari NoharaFranck Mauvais-Jarvis
May 29, 2008·European Journal of Endocrinology·Nectaria XitaAgathocles Tsatsoulis
Nov 30, 2013·Human Reproduction Update·M C RichardsonN S Macklon
May 16, 2014·The Journal of Endocrinology·Xiaonan YanJiayin Liu
May 31, 2014·Physiology & Behavior·Joanna H SliwowskaMichael N Lehman
May 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group
Mar 10, 2015·International Journal of Endocrinology and Metabolism·Zahra DaneshianAzita Zadeh Vakili
Feb 18, 2011·Journal of Women's Health·Sharon Stein MerkinDavid Siscovick
Feb 19, 2013·Endocrinology·Michael T SellixMichael Menaker
Apr 25, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kazunari NoharaFranck Mauvais-Jarvis
Sep 2, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Sven M Carlsen
Sep 27, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A HunterW Atiomo
Jan 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aleisha M MooreRebecca E Campbell
Sep 8, 2009·Molecular and Cellular Endocrinology·Nectaria Xita, Agathocles Tsatsoulis
Jul 12, 2008·Clinical Endocrinology·Helen MasonStephen L Atkin
Sep 16, 2010·Annals of the New York Academy of Sciences·Vincenzina BruniDaniela Nuvolone
Dec 11, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Radha KothariNadia Micali
Sep 9, 2015·Journal of Developmental Origins of Health and Disease·A J KermackN S Macklon
Aug 10, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Priscila Daniele Ramos CiriloSilvia Regina Rogatto
Oct 22, 2013·Animal Reproduction Science·Katarzyna Knapczyk-StworaMaria Slomczynska

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