Review: mediation of the ocular response to injury

Journal of Ocular Pharmacology
W G Unger

Abstract

The structure of the anterior segment of the eye provide aqueous humour for metabolic traffic, regulation of intraocular pressure and the maintenance of a functional permeability barrier to separate internal compartments from general systemic influences. Irritative and injurous insults to the eye elicit an acute defensive miotic and vascular response which upsets the aqueous dynamics and provokes the influx of blood plasma proteins into the aqueous chambers. These events are initiated by antidromic activation of sensory elements within the anterior segment, releasing substance P and calcitonin gene-related peptide (CGRP) which, in lower mammals at least, stimulate respectively the miotic and vascular reactions. Considerable species differences can be found in the responsiveness of the eye to injury and in the effects of exogenous CGRP and substance P.

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Citations

Sep 11, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anna Koralewska-MakárBerndt Ehinger
Nov 1, 1995·British Journal of Pharmacology·Z Y Wang, R Håkanson
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Feb 25, 2014·Experimental Eye Research·Hong ZhangJonathan G Crowston
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Sep 8, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·P ChetoniM F Saettone
Sep 8, 2000·American Journal of Veterinary Research·R E HamorD J Schaeffer
Oct 12, 2001·Acta Ophthalmologica Scandinavica·A Koralewska-MakárB Ehinger
Nov 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erik J SuuronenMay Griffith
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Anna Koralewska-MakárBerndt Ehinger
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Jul 6, 2010·Current Eye Research·Eliana B SoutoMaria Luisa Garcia
Oct 16, 1999·Current Eye Research·T TaniguchiY Kitazawa
May 7, 2013·Ophthalmic Plastic and Reconstructive Surgery·Ann ShueJeremiah P Tao

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