Review: Microbial endocrinology: intersection of microbiology and neurobiology matters to swine health from infection to behavior

Animal : an International Journal of Animal Bioscience
Joshua M Lyte, Mark Lyte

Abstract

From birth to slaughter, pigs are in constant interaction with microorganisms. Exposure of the skin, gastrointestinal and respiratory tracts, and other systems allows microorganisms to affect the developmental trajectory and function of porcine physiology as well as impact behavior. These routes of communication are bi-directional, allowing the swine host to likewise influence microbial survival, function and community composition. Microbial endocrinology is the study of the bi-directional dialogue between host and microbe. Indeed, the landmark discovery of host neuroendocrine systems as hubs of host-microbe communication revealed neurochemicals act as an inter-kingdom evolutionary-based language between microorganism and host. Several such neurochemicals are stress catecholamines, which have been shown to drastically increase host susceptibility to infection and augment virulence of important swine pathogens, including Clostridium perfringens. Catecholamines, the production of which increase in response to stress, reach the epithelium of multiple tissues, including the gastrointestinal tract and lung, where they initiate diverse responses by members of the microbiome as well as transient microorganisms, including pathogens and...Continue Reading

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Citations

Oct 19, 2019·Animal : an International Journal of Animal Bioscience·E RouraF R Dunshea
Dec 23, 2020·Environmental Microbiology·Quentin PerraudIsabelle J Schalk
Mar 3, 2021·Archives of Oral Biology·Iago Torres CortêsGilson Cesar Nobre Franco
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Sha JiangHeng-Wei Cheng
May 18, 2021·Animal Nutrition·Lijuan FanWenkai Ren
Jul 3, 2021·Frontiers in Microbiology·Anne-Lise PocheronPatricia Parnet
Aug 6, 2021·Critical Reviews in Microbiology·Ousman BajinkaShakeel Ahmed Saleem

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