Review of a novel disease entity, immunoglobulin G4-related disease

Journal of the Korean Association of Oral and Maxillofacial Surgeons
Takashi MaeharaSeiji Nakamura

Abstract

Immunoglobulin G4 (IgG4)-related dacryoadenitis and sialoadenitis (IgG4-DS) are part of a multiorgan fibroinflammatory condition of unknown etiology termed IgG4-related disease (IgG4-RD), which has been recognized as a single diagnostic entity for less than 15 years. Histopathologic examination is critical for diagnosis of IgG4-RD. CD4+ T and B cells, including IgG4-expressing plasma cells, constitute the major inflammatory cell populations in IgG4-RD and are thought to cause organ damage and tissue fibrosis. Patients with IgG4-RD who have active, untreated disease exhibit significant increase of IgG4-secreting plasmablasts in the blood. Considerable insight into the immunologic mechanisms of IgG4-RD has been achieved in the last decade using novel molecular biology approaches, including next-generation and single-cell RNA sequencing. Exploring the interactions between CD4+ T cells and B lineage cells is critical for understanding the pathophysiology of IgG4-RD. Establishment of pathogenic T cell clones and identification of antigens specific to these clones constitutes the first steps in determining the pathogenesis of the disease. Herein, the clinical features and mechanistic insights regarding pathogenesis of IgG4-RD were re...Continue Reading

References

Apr 29, 2009·Gut·T KamisawaM Omata
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Nov 29, 2011·Current Opinion in Immunology·Shiv PillaiAnnaiah Cariappa
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeJohn H Stone
Jun 30, 2012·Journal of Gastroenterology·Tomohiro WatanabeTsutomu Chiba
Jul 25, 2012·Arthritis Research & Therapy·Hiroto TsuboiTakayuki Sumida
Oct 17, 2012·Seminars in Diagnostic Pathology·Wah Cheuk, John K C Chan
Nov 14, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Alan N BaerUNKNOWN Sjögren's International Collaborative Alliance
Dec 18, 2012·Clinical Oral Investigations·Masafumi MoriyamaSeiji Nakamura
Jun 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Edward K HuJohn H Stone
Oct 12, 2013·Annual Review of Pathology·Vinay S MahajanJohn H Stone
Feb 12, 2014·Seminars in Arthritis and Rheumatism·Zachary S WallaceJohn H Stone
Mar 22, 2014·Annals of the Rheumatic Diseases·Mollie N CarruthersJohn H Stone
May 13, 2014·The Journal of Allergy and Clinical Immunology·Hamid MattooShiv Pillai
May 13, 2014·Annals of the Rheumatic Diseases·Zachary S WallaceJohn H Stone
Aug 22, 2014·Annals of the Rheumatic Diseases·Emanuel Della-TorreJohn H Stone
Dec 3, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sachiko FurukawaSeiji Nakamura
Dec 8, 2014·Lancet·Terumi KamisawaJohn H Stone
Feb 11, 2015·Annals of the Rheumatic Diseases·Mollie N CarruthersJohn H Stone
Mar 27, 2015·Arthritis & Rheumatology·A KhosroshahiUNKNOWN Second International Symposium on IgG4-Related Disease
May 2, 2015·PloS One·Hongwu DuGuangyu Chen
Jul 22, 2015·Arthritis Research & Therapy·Wei LiGuang-Yan Yu
Mar 12, 2016·Gut·Masahiro ShiokawaTsutomu Chiba
Mar 15, 2016·The Journal of Allergy and Clinical Immunology·Hamid MattooShiv Pillai
Jul 1, 2016·Annals of the Rheumatic Diseases·Takashi MaeharaShiv S Pillai
Jul 20, 2016·Zeitschrift für Rheumatologie·C A Perugino, J H Stone
Aug 21, 2016·Gut·Atsushi MasamuneUNKNOWN Research Committee of Intractable Pancreas Diseases in Japan

❮ Previous
Next ❯

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Song-Chou HsiehChia-Li Yu
Feb 2, 2021·European Journal of Radiology·Alina Denisa DraganRavi Kumar Lingam

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
flow cytometry
transgenic

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

International Journal of Oral and Maxillofacial Surgery
Takashi MaeharaSeiji Nakamura
Annales de pathologie
Mikael Ebbo, Nicolas Schleinitz
Modern Rheumatology
Motohisa YamamotoYasuhisa Shinomura
© 2021 Meta ULC. All rights reserved