Review of autonomic dysfunction, cardiac arrhythmias, and epileptogenic activity

Journal of Clinical Pharmacology
Claire M Lathers, Paul L Schraeder

Abstract

Similarities in autonomic dysfunction associated with arrhythmias and death in animal models for digitalis toxicity, myocardial infarction, psychotropic toxicity, and epileptogenic activity are reviewed. When intravenous (IV) pentylenetetrazol was given to anesthetized cats, autonomic dysfunction was associated with both interictal and ictal epileptogenic activity. The autonomic dysfunction was manifested by the fact that autonomic cardiac nerves did not always respond in a predictable manner to changes in blood pressure, the development of a marked increase in variability in mean autonomic cardiac nerve discharge, and the appearance of a very large increase in the variability of the discharge rate of parasympathetic nerves first and then secondly in sympathetic discharge. The altered autonomic cardiac nerve discharge was associated with interictal epileptogenic activity and arrhythmia, which may contribute to sudden unexplained death in patients with epilepsy. Since phenobarbital (20 mg/kg, IV 60 min prior to pentylenetetrazol) exhibited anticonvulsant, but not antiarrhythmic and neural depressant activity, phenobarbital does not appear to be the ideal agent to prevent the autonomic dysfunction associated with epileptogenic ac...Continue Reading

References

Jun 1, 1979·The American Journal of Cardiology·J I Haft
Oct 1, 1979·Epilepsia·M Iivanainen, J Lehtinen
May 6, 1978·British Medical Journal·A A McLeod, D E Jewitt
Jun 4, 1977·British Medical Journal·G D SchottD E Jewitt
Nov 1, 1977·Archives of Neurology·P L Schraeder, G G Celesia
Jun 11, 1975·Neurology·C F TerrenceJ A Perper
Feb 10, 1986·Life Sciences·C M Lathers, L J Lipka
Jun 1, 1974·Epilepsia·J J Zieliński
Feb 1, 1974·Circulation·R A GillisL Barr
Jul 1, 1971·Neurology·C S Hirsch, D L Martin
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J Roberts
Jan 1, 1983·Journal of the American College of Cardiology·T N James
Nov 10, 1980·Life Sciences·C M Lathers, J Roberts
Dec 25, 1952·The Tohoku Journal of Experimental Medicine·O ORIHARA
Jan 1, 1964·Circulation Research·J HAN, G K MOE

❮ Previous
Next ❯

Citations

Jun 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P NovakG Remillard
Sep 1, 1987·Electroencephalography and Clinical Neurophysiology·C M LathersF L Weiner
Jan 1, 1989·Epilepsy Research·P L Schraeder, C M Lathers
Mar 1, 1993·Seizure : the Journal of the British Epilepsy Association·M E DrakeA Kay
Jun 17, 1998·Seizure : the Journal of the British Epilepsy Association·M E DrakeC M Castleberry
Aug 30, 2008·Epilepsia·Cameron S MetcalfSteven L Bealer
Nov 5, 2011·Epilepsia·Ahmed-Ramadan SadekDavid Allen
Jan 10, 2009·Journal of Integrative Neuroscience·Vladimir M PokrovskiiAnatoliy A Nechepurenko
Feb 8, 2002·Journal of Clinical Pharmacology·Claire M Lathers, Paul L Schraeder
Aug 5, 2009·Autonomic Neuroscience : Basic & Clinical·Harumi HottaMark Stewart
May 2, 2009·Epilepsy & Behavior : E&B·Claire M Lathers
Jul 17, 2004·Epilepsy & Behavior : E&B·M Said BerilgenBulent Mungen
Sep 6, 2006·Epilepsy Research·T N SathyaprabhaT R Raju
Jul 1, 1988·Journal of Clinical Pharmacology·C M LathersI Agarwal
Mar 1, 1987·Journal of Clinical Pharmacology·L J Lipka, C M Lathers
Jan 21, 2006·Epilepsy Research·Paul L SchraederElson L So
Aug 18, 2012·Seizure : the Journal of the British Epilepsy Association·A MeghanaP Satishchandra
Mar 1, 1996·Seizure : the Journal of the British Epilepsy Association·S J TavernorC Gifford
Aug 10, 2000·Circulation·S S ChughJ L Titus
Feb 9, 2010·The American Journal of Forensic Medicine and Pathology·Natasha E HolmesTony M Korman
Dec 7, 2007·Expert Review of Neurotherapeutics·Ann Johnston, Phil Smith
May 26, 2021·International Journal of Neural Systems·Lars StumppRiem El Tahry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.