Review of biophysical factors affecting osteogenic differentiation of human adult adipose-derived stem cells

Biophysics Reviews
Georgina To'a Salazar, Osamu Ohneda

Abstract

Developing bone is subject to the control of a broad variety of influences in vivo. For bone repair applications, in vitro osteogenic assays are routinely used to test the responses of bone-forming cells to drugs, hormones, and biomaterials. Results of these assays are used to predict the behavior of bone-forming cells in vivo. Stem cell research has shown promise for enhancing bone repair. In vitro osteogenic assays to test the bone-forming response of stem cells typically use chemical solutions. Stem cell in vitro osteogenic assays often neglect important biophysical cues, such as the forces associated with regular weight-bearing exercise, which promote bone formation. Incorporating more biophysical cues that promote bone formation would improve in vitro osteogenic assays for stem cells. Improved in vitro osteogenic stimulation opens opportunities for "pre-conditioning" cells to differentiate towards the desired lineage. In this review, we explore the role of select biophysical factors-growth surfaces, tensile strain, fluid flow and electromagnetic stimulation-in promoting osteogenic differentiation of stem cells from human adipose. Emphasis is placed on the potential for physical microenvironment manipulation to translate ti...Continue Reading

References

Oct 31, 2000·Biomaterials·K J BurgJ F Kellam
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Nov 24, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Stefan LendeckelHans-Peter Howaldt
Jul 28, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hidemi HattoriMasayuki Ishihara
Dec 20, 2005·Gene·Janet RubinChristopher Rae Jacobs
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jul 4, 2007·Journal of Biomedical Materials Research. Part a·Natsuko KakudoKenji Kusumoto
Aug 10, 2007·American Journal of Physiology. Cell Physiology·Michelle E WallElizabeth G Loboa
Mar 11, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sagar D Joshi, Ken Webb
Mar 13, 2008·Science Signaling·Rebecca G Wells, Dennis E Discher
May 22, 2008·Journal of Tissue Engineering and Regenerative Medicine·Lauren S SefcikEdward A Botchwey
Jun 20, 2008·Journal of Biomedical Materials Research. Part a·A J Dulgar-TullochR W Siegel
Aug 22, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yen Kim LuuClinton T Rubin
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Suvi HaimiRiitta Suuronen
Jan 27, 2009·International Journal of Oral and Maxillofacial Surgery·K MesimäkiR Suuronen
Jan 29, 2009·Journal of Cell Science·Emily J ArnsdorfChristopher R Jacobs
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Diana E Jaalouk, Jan Lammerding
Apr 24, 2009·Annals of Plastic Surgery·Courtney R ReedJohn A van Aalst
Aug 6, 2009·Journal of Materials Science. Materials in Medicine·Gerardo MarinoAlfonso Barbarisi
Aug 15, 2009·Tissue Engineering. Part a·Mirjam FröhlichGordana Vunjak-Novakovic
Oct 10, 2009·Journal of Biomechanics·Seth D McCullenElizabeth G Loboa
Oct 15, 2009·Tissue Engineering. Part a·Kyle E HammerickMichael T Longaker
Feb 17, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Taro ShojiTakayuki Asahara
Feb 27, 2010·Tissue Engineering. Part a·Bettina LindroosSusanna Miettinen
Mar 11, 2010·Annals of Biomedical Engineering·E M KearneyV A Campbell
Mar 24, 2010·Biomechanics and Modeling in Mechanobiology·Liyue LiuJinfu Wang
Jul 14, 2010·Journal of Cellular Physiology·Arnaud ScherberichIvan Martin
Sep 8, 2010·Methods in Cell Biology·Benjamin Kim Kiat TeoEvelyn K F Yim
Nov 18, 2010·Methods in Molecular Biology·Robert Jan KroezeMarco N Helder
Feb 10, 2011·Stem Cells·Benjamin Levi, Michael T Longaker
Feb 23, 2011·Tissue Engineering. Part B, Reviews·Josephine C BodleElizabeth G Loboa
Mar 18, 2011·Tissue Engineering. Part C, Methods·Raphael GorodetskyWilliam H McBride

❮ Previous
Next ❯

Citations

Jul 22, 2017·PloS One·Gladys FilliatPeter J Richards
Apr 3, 2020·Journal of Cellular Physiology·Hajar Shafaei, Hossein Kalarestaghi
Aug 23, 2020·International Journal of Molecular Sciences·Kar Wey YongAlistair C Cowie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.