PMID: 7580496Sep 30, 1995Paper

Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice

BMJ : British Medical Journal
S P Fisher-HochJ B McCormick

Abstract

To investigate two hospital outbreaks of Lassa fever in southern central Nigeria. Hospitals and clinics in urban and rural areas of Imo State, Nigeria. Medical records were reviewed in hospitals and clinics in both areas. Patients with presumed and laboratory confirmed Lassa fever were identified and contracts traced. Hospital staff, patients, and local residents were questioned, records were carefully reviewed, and serum samples were taken. Serum samples were assayed for antibody specific to Lassa virus, and isolates of Lassa virus were obtained. Among 34 patients with Lassa fever, including 20 patients, six nurses, two surgeons, one physician, and the son of a patient, there were 22 deaths (65% fatality rate). Eleven cases were laboratory confirmed, five by isolation of virus. Most patients had been exposed in hospitals (attack rate in patients in one hospital 55%). Both outbreak hospitals were inadequately equipped and staffed, with poor medical practice. Compelling, indirect evidence revealed that parenteral drug rounds with sharing of syringes, conducted by minimally educated and supervised staff, fuelled the epidemic among patients. Staff were subsequently infected during emergency surgery and while caring for nosocomiall...Continue Reading

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Citations

Oct 9, 2001·Reviews in Medical Virology·S P Fisher-Hoch, J B McCormick
Jul 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·M D BajaniT G Ksiazek
Mar 5, 2003·Antiviral Research·Christian DrostenStephan Günther
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Jul 14, 2007·Vector Borne and Zoonotic Diseases·Elisabeth Fichet-CalvetJan Ter Meulen
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Aug 22, 2008·Journal of Virology·Ryan A LarsonSean M Amberg
Jan 15, 2010·Journal of Virology·Katrin SchlieWolfgang Garten
Jul 11, 2000·Journal of Virology·S P Fisher-HochJ B McCormick
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Dec 23, 1995·BMJ : British Medical Journal·M E Wilson
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