Review of clinical applications of radiation-enhancing nanoparticles

Biotechnology Reports
N ScherV Calugaru

Abstract

Clinical evidence of the radiation-enhancing effects of nanoparticles has emerged. We searched the literature in English and French on PubMed up to October 2019. The search term was "nanoparticle" AND "radiotherapy", yielding 1270 results. The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2/3 trial. There are six ongoing phase 1/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer. So far, intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma.

References

Jul 12, 2002·Clinical Oncology : a Journal of the Royal College of Radiologists·H LukkaUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Gynecology Disease Site Group
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deepak KhuntiaMinesh P Mehta
Sep 15, 2006·The New England Journal of Medicine·Jean-François BossetUNKNOWN EORTC Radiotherapy Group Trial 22921
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
Oct 15, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·David G PfisterUNKNOWN National Comprehensive Cancer Network
Mar 19, 2016·Cancer Letters·Chloé RancouleCyrus Chargari
Aug 24, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Julie MarillSébastien Paris

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Citations

Nov 9, 2021·International Journal of Radiation Biology·Shirley Lehnert

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Methods Mentioned

BETA
X-ray
surgical resection

Clinical Trials Mentioned

NCT01433068
NCT01946867
NCT02901483
NCT03308604
NCT02805894
NCT02721056
NCT02465593
NCT02820454
NCT04094077
NCT03818386

Software Mentioned

RAD

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