PMID: 9647137Jul 1, 1998Paper

Review of efficacy parameters

The Annals of Thoracic Surgery
P Pouard

Abstract

The deleterious effects of cardiopulmonary bypass are greater in pediatric patients than in adults. The use of aprotinin to manipulate hemostasis has become an important factor in attempts to reduce adverse consequences of these effects. This article reviews the literature on the use of aprotinin in pediatric cardiac surgery. Available studies have many deficiencies, often including lack of placebo control, nonhomogeneous populations and procedures, and absence of information on aprotinin plasma concentrations. Comparison of trial results is further complicated by differences in dose regimens, heparin-protamine protocols, and priming. Further trials are required to adequately assess aprotinin effect on platelet preservation, particularly in neonates, to evaluate aprotinin's antiinflammatory action, and to determine optimum dosages to achieve specific objectives. Aprotinin in pediatric cardiac surgery has been found to be associated with no adverse effects, to decrease fibrinolytic and probably platelet activation, and to offer important clinical benefits in specific groups of patients.

References

Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S WestabyR Pillai
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J HimmelfarbE McMonagle
Dec 1, 1995·The Annals of Thoracic Surgery·P A PenkoskeW Gibb
Apr 1, 1996·The Annals of Thoracic Surgery·M C SeghayeG von Bernuth
Nov 1, 1996·The Annals of Thoracic Surgery·J S TweddellS B Litwin
Dec 1, 1996·Anesthesia and Analgesia·C C D'ErricoE L Bove

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Citations

Jan 6, 2000·Journal of Cardiothoracic and Vascular Anesthesia·G D Williams, C Ramamoorthy
Mar 3, 2004·The Annals of Thoracic Surgery·Mary M McCallScott M Bradley
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P P PunjabiK M Taylor
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Emad B MossadJohn Apostolakis
Aug 21, 2008·Anesthesia and Analgesia·Chinnamuthu MurugesanKanchi Muralidhar
Feb 12, 2000·Journal of Medicinal Chemistry·D LeungD P Fairlie
Jul 27, 2001·Anesthesiology Clinics of North America·S L Barcelona, C J Coté

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