PMID: 9187827Jun 1, 1997Paper

Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies

Clinics in Chest Medicine
B Hausen, R E Morris

Abstract

The history, pharmacokinetics, mechanisms of action, and experimental as well as clinical data on the immunosuppressive potential of the novel drugs tacrolimus (FK506), sirolimus (rapamycin), mycophenolic acid (mycophenolate mofetil), and leflunomide (and its malononitriloamide analogues) are provided. Novel approaches with the following conventional immunosuppressants are outlined: methotrexate, aerosolized immunosuppression and the implementation of steroid taper. Total lymphoid irradiation and photopheresis for treatment of recurrent rejection are also discussed.

References

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Citations

Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B HausenR E Morris
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B HausenR E Morris
Apr 8, 1999·The New England Journal of Medicine·S M Arcasoy, R M Kotloff
Dec 12, 2001·Transplantation·D L DeMeo, L C Ginns
Mar 31, 2000·Current Opinion in Pulmonary Medicine·A Boehler, M Estenne
Mar 17, 2004·Current Opinion in Pulmonary Medicine·Andrew Chan, Roblee Allen
Jan 31, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marietta von Suesskind-SchwendiKarla Lehle
Mar 27, 2002·The Psychiatric Clinics of North America·Kathy Coffman
Mar 16, 2001·Expert Opinion on Pharmacotherapy·G CiancioJ Miller
Feb 13, 2001·Annual Review of Medicine·D L DeMeo, L C Ginns
Feb 24, 2009·Journal of Pharmacological Sciences·Christianne B V ScaramelloValéria do M N Cunha
Jan 5, 2002·AACN Clinical Issues·D M Lanuza, M A McCabe
Mar 30, 2005·Therapeutic Drug Monitoring·Sara E RosenbaumFatemeh Akhlaghi
Oct 29, 2002·International Immunopharmacology·Markéta JelinkováBlanka Ríhová

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