Review of interventions for the prevention and control of folate and vitamin B12 deficiencies

Food and Nutrition Bulletin
José F CorderoR J Berry

Abstract

Folate and vitamin B12 deficiencies represent important and evolving global health challenges that contribute to the global burden of anemia, neurologic conditions, neurodevelopmental disorders, and birth defects. We present a review of population-based programs designed to increase consumption of folates and vitamin B12. A folic acid supplementation program targeting couples prior to marriage in China has led to optimal consumption of supplements containing folic acid and a significant reduction of neural tube defects (NTD). Supplementation programs that use mass community education show some promise, but have not been shown to be as effective as targeted education. The success of supplementation programs hinges on a strong and persistent educational component and access to the supplements. Fortification with folic acid has been shown to reduce the prevalence of NTD in the countries where it has been implemented. Challenges to fortification programs include identifying the appropriate delivery vehicles, setting the optimal fortification level, sustaining the quality assurance of the fortification level, and addressing regulatory challenges and trade barriers of commercially fortified flours. Supplementation and fortification a...Continue Reading

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Citations

Apr 1, 2010·Nutrients·Saloomeh Moslehi-JenabianLene Jespersen
Dec 18, 2013·Annals of the New York Academy of Sciences·Michael L DunnBarbara P Klein
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Ryan James Wood-BradleyJames Andrew Armitage
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Jul 12, 2016·Paediatrics & Child Health·Noam AmiUNKNOWN Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee
Apr 7, 2010·Journal of the American College of Nutrition·Lester M ArguellesXiaobin Wang

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