Review of Mathematical Models of Vaccination for Preventing Congenital Cytomegalovirus Infection.

The Journal of Infectious Diseases
Tatiana M LanzieriStanley A Plotkin

Abstract

Several cytomegalovirus (CMV) vaccine candidates are under development. To reduce the burden of congenital CMV infection, potential strategies under consideration include vaccination of adult women, adolescent girls, and/or young children (both sexes). We reviewed 5 studies that used infectious disease modeling to assess the potential impact of vaccination for preventing congenital CMV infection. All models assumed CMV vaccination would prevent primary infection and 2 models also assumed prevention of reinfections and reactivations. Despite differences in structure, assumptions, and population data, infant vaccination (both sexes) was the optimal strategy in all models, but in 1 model vaccinating seronegative women at 19-21 years of age was also optimal (for duration of vaccine protection ≥8 years). In 3 models, infant vaccination increased average age at primary infection as a result of decreased secondary transmission (herd immunity) combined with waning vaccine-induced immunity. This effect could increase the risk of congenital CMV infections in populations where primary CMV infection occurs early in childhood but could be minimized by administering a second dose of vaccine during adolescence. Understanding vaccine efficacy ...Continue Reading

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Citations

Jan 22, 2021·Journal of Medical Virology·Angelica RicoTatiana M Lanzieri
Mar 31, 2021·Journal of Clinical Laboratory Analysis·Rihwa ChoiEun Hee Lee

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